Cell atlas - KIAA1109 - The Human Protein Atlas

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KIAA1109

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Nucleoplasm

Human cell
	Centrosome
	Nucleoplasm

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GENERAL INFORMATION
Gene name	KIAA1109
Gene description	KIAA1109
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the centrosome & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Centrosome (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA038076
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the centrosome & nucleoplasm.

Main location

Nucleoplasm (approved), Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038076	A-431	Nucleoplasm
	HPA038076	A-431	Centrosome
	HPA038076	U-2 OS	Nucleoplasm
	HPA038076	U-2 OS	Centrosome
	HPA038076	U-251 MG	Nucleoplasm
	HPA038076	U-251 MG	Centrosome

GENE INFORMATION
Gene name	KIAA1109 (HGNC Symbol)
Synonyms	FLJ21404, FSA, KIAA1371, Tweek
Description	KIAA1109 (HGNC Symbol)
Entrez gene summary	This gene is located on the long arm of chromosome 4 in a region that is associated with susceptibility to celiac disease. The encoded protein is similar to a Chinese hamster protein that is associated with spermatocyte and adipocyte differentiation. The C-terminus of the protein is also similar to a Caenorhabditis elegans protein that plays a role in lipid storage. In mammals, this protein is thought to function in the regulation of epithelial growth and differentiation, and in tumor development. [provided by RefSeq, Oct 2009]
Chromosome	4
Cytoband	q27
Chromosome location (bp)	122152333 - 122362758
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138688 (version 83.38)
Entrez gene	84162
UniProt	Q2LD37 (UniProt - Evidence at protein level)
neXtProt	NX_Q2LD37
Antibodypedia	KIAA1109 antibodies

PROTEIN BROWSER

KIAA1109-001	KIAA1109-003	KIAA1109-004	KIAA1109-006	KIAA1109-007	KIAA1109-008	KIAA1109-009	KIAA1109-010	KIAA1109-011	KIAA1109-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KIAA1109-001 ENSP00000264501 ENST00000264501	Q2LD37 [Direct mapping] Uncharacterized protein KIAA1109 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030856 [regulation of epithelial cell differentiation] Show all	5005 aa 555.5 kDa	No	1
KIAA1109-003 ENSP00000413018 ENST00000449251	H7C3N8 [Direct mapping] Uncharacterized protein KIAA1109 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		164 aa 18 kDa	No	0
KIAA1109-004 ENSP00000398039 ENST00000424425	H7C121 [Direct mapping] Uncharacterized protein KIAA1109 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		1247 aa 140.1 kDa	No	0
KIAA1109-006 ENSP00000394909 ENST00000446180	H7C0G8 [Direct mapping] Uncharacterized protein KIAA1109 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		1447 aa 158.3 kDa	No	0
KIAA1109-007 ENSP00000393219 ENST00000419325	H7C070 [Direct mapping] Uncharacterized protein KIAA1109 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		1638 aa 180.5 kDa	No	0
KIAA1109-008 ENSP00000397543 ENST00000442707	H7C0Y8 [Direct mapping] Uncharacterized protein KIAA1109 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		197 aa 20.3 kDa	No	0
KIAA1109-009 ENSP00000304374 ENST00000306802	H3BLT5 [Direct mapping] Uncharacterized protein KIAA1109 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		1381 aa 152.6 kDa	No	0
KIAA1109-010 ENSP00000410874 ENST00000438707	H0Y781 [Direct mapping] Uncharacterized protein KIAA1109 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		1674 aa 185.2 kDa	No	0
KIAA1109-011 ENSP00000408229 ENST00000421930	H7C2X5 [Direct mapping] Uncharacterized protein KIAA1109 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		208 aa 22.5 kDa	No	0
KIAA1109-201 ENSP00000373390 ENST00000388738	Q2LD37 [Direct mapping] Uncharacterized protein KIAA1109 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030856 [regulation of epithelial cell differentiation] Show all	5005 aa 555.5 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.