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BMPR1B

CANCER ATLAS

Gene description

 Bone morphogenetic protein receptor, type IB

Protein class

 CD markers, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB009634

GENE INFORMATION

Gene name

 BMPR1B (HGNC Symbol)

Synonyms

 ALK6, CDw293

Description

 Bone morphogenetic protein receptor, type IB (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Chromosome

 4

Cytoband

 q22.3

Chromosome location (bp)

 94757968 - 95158448

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138696 (version 83.38)

Entrez gene

 658

UniProt

 O00238 (UniProt - Evidence at protein level)

neXtProt

 NX_O00238

Antibodypedia

 BMPR1B antibodies

PROTEIN BROWSER
BMPR1B-001
BMPR1B-002
BMPR1B-003
BMPR1B-004
BMPR1B-005
BMPR1B-006
BMPR1B-007
BMPR1B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BMPR1B-001
ENSP00000426617
ENST00000515059
O00238 [Direct mapping]
Bone morphogenetic protein receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0001501 [skeletal system development]
GO:0001502 [cartilage condensation]
GO:0001550 [ovarian cumulus expansion]
GO:0001654 [eye development]
GO:0001948 [glycoprotein binding]
GO:0002063 [chondrocyte development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0035108 [limb morphogenesis]
GO:0042698 [ovulation cycle]
GO:0043235 [receptor complex]
GO:0045597 [positive regulation of cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0060350 [endochondral bone morphogenesis]
GO:0061036 [positive regulation of cartilage development]
GO:0071773 [cellular response to BMP stimulus]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:1990712 [HFE-transferrin receptor complex]
Show all
 502 aa
56.9 kDa 		No 1
BMPR1B-002
ENSP00000378389
ENST00000394931
O00238 [Direct mapping]
Bone morphogenetic protein receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0001501 [skeletal system development]
GO:0001502 [cartilage condensation]
GO:0001550 [ovarian cumulus expansion]
GO:0001654 [eye development]
GO:0001948 [glycoprotein binding]
GO:0002063 [chondrocyte development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0035108 [limb morphogenesis]
GO:0042698 [ovulation cycle]
GO:0043235 [receptor complex]
GO:0045597 [positive regulation of cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0060350 [endochondral bone morphogenesis]
GO:0061036 [positive regulation of cartilage development]
GO:0071773 [cellular response to BMP stimulus]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:1990712 [HFE-transferrin receptor complex]
Show all
 502 aa
56.9 kDa 		No 1
BMPR1B-003
ENSP00000264568
ENST00000264568
O00238 [Direct mapping]
Bone morphogenetic protein receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0001501 [skeletal system development]
GO:0001502 [cartilage condensation]
GO:0001550 [ovarian cumulus expansion]
GO:0001654 [eye development]
GO:0001948 [glycoprotein binding]
GO:0002063 [chondrocyte development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0035108 [limb morphogenesis]
GO:0042698 [ovulation cycle]
GO:0043235 [receptor complex]
GO:0045597 [positive regulation of cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0060350 [endochondral bone morphogenesis]
GO:0061036 [positive regulation of cartilage development]
GO:0071773 [cellular response to BMP stimulus]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:1990712 [HFE-transferrin receptor complex]
Show all
 502 aa
56.9 kDa 		No 1
BMPR1B-004
ENSP00000421144
ENST00000506363
D6RGW8 [Direct mapping]
Bone morphogenetic protein receptor type-1B
Show all
Predicted intracellular proteins
Show all
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
Show all
 125 aa
13.9 kDa 		No 0
BMPR1B-005
ENSP00000425444
ENST00000512312
O00238 [Direct mapping]
Bone morphogenetic protein receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0001501 [skeletal system development]
GO:0001502 [cartilage condensation]
GO:0001550 [ovarian cumulus expansion]
GO:0001654 [eye development]
GO:0001948 [glycoprotein binding]
GO:0002063 [chondrocyte development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0035108 [limb morphogenesis]
GO:0042698 [ovulation cycle]
GO:0043235 [receptor complex]
GO:0045597 [positive regulation of cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0060350 [endochondral bone morphogenesis]
GO:0061036 [positive regulation of cartilage development]
GO:0071773 [cellular response to BMP stimulus]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:1990712 [HFE-transferrin receptor complex]
Show all
 502 aa
56.9 kDa 		No 1
BMPR1B-006
ENSP00000424693
ENST00000502683
D6RAW8 [Direct mapping]
Bone morphogenetic protein receptor type-1B
Show all
Predicted intracellular proteins
Show all
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
Show all
 114 aa
12.5 kDa 		No 0
BMPR1B-007
ENSP00000421671
ENST00000509540
O00238 [Direct mapping]
Bone morphogenetic protein receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0001501 [skeletal system development]
GO:0001502 [cartilage condensation]
GO:0001550 [ovarian cumulus expansion]
GO:0001654 [eye development]
GO:0001948 [glycoprotein binding]
GO:0002063 [chondrocyte development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0035108 [limb morphogenesis]
GO:0042698 [ovulation cycle]
GO:0043235 [receptor complex]
GO:0045597 [positive regulation of cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0060350 [endochondral bone morphogenesis]
GO:0061036 [positive regulation of cartilage development]
GO:0071773 [cellular response to BMP stimulus]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:1990712 [HFE-transferrin receptor complex]
Show all
 502 aa
56.9 kDa 		No 1
BMPR1B-201
ENSP00000401907
ENST00000440890
O00238 [Direct mapping]
Bone morphogenetic protein receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0001501 [skeletal system development]
GO:0001502 [cartilage condensation]
GO:0001550 [ovarian cumulus expansion]
GO:0001654 [eye development]
GO:0001948 [glycoprotein binding]
GO:0002062 [chondrocyte differentiation]
GO:0002063 [chondrocyte development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005025 [transforming growth factor beta receptor activity, type I]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009953 [dorsal/ventral pattern formation]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030425 [dendrite]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0031290 [retinal ganglion cell axon guidance]
GO:0035108 [limb morphogenesis]
GO:0042698 [ovulation cycle]
GO:0043010 [camera-type eye development]
GO:0043025 [neuronal cell body]
GO:0043235 [receptor complex]
GO:0045597 [positive regulation of cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0060041 [retina development in camera-type eye]
GO:0060350 [endochondral bone morphogenesis]
GO:0061036 [positive regulation of cartilage development]
GO:0071773 [cellular response to BMP stimulus]
GO:1902043 [positive regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:1990712 [HFE-transferrin receptor complex]
Show all
 532 aa
60.6 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.