Tissue expression of RAP1GDS1 - Summary - The Human Protein Atlas

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RAP1GDS1

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	RAP1GDS1
Gene description	RAP1, GTP-GDP dissociation stimulator 1
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA019060
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	RAP1GDS1 (HGNC Symbol)
Synonyms	SmgGDS
Description	RAP1, GTP-GDP dissociation stimulator 1 (HGNC Symbol)
Entrez gene summary	The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]
Chromosome	4
Cytoband	q23
Chromosome location (bp)	98261384 - 98443861
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138698 (version 83.38)
Entrez gene	5910
UniProt	P52306 (UniProt - Evidence at protein level)
neXtProt	NX_P52306
Antibodypedia	RAP1GDS1 antibodies

PROTEIN BROWSER

RAP1GDS1-001	RAP1GDS1-002	RAP1GDS1-004	RAP1GDS1-005	RAP1GDS1-006	RAP1GDS1-007	RAP1GDS1-008	RAP1GDS1-011	RAP1GDS1-016	RAP1GDS1-017	RAP1GDS1-020	RAP1GDS1-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RAP1GDS1-001 ENSP00000386153 ENST00000408927	P52306 [Direct mapping] Rap1 GTPase-GDP dissociation stimulator 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration] GO:0043547 [positive regulation of GTPase activity] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:0070062 [extracellular exosome] Show all	607 aa 66.3 kDa	No	0
RAP1GDS1-002 ENSP00000369503 ENST00000380158	P52306 [Direct mapping] Rap1 GTPase-GDP dissociation stimulator 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration] GO:0043547 [positive regulation of GTPase activity] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:0070062 [extracellular exosome] Show all	559 aa 61.1 kDa	No	0
RAP1GDS1-004 ENSP00000264572 ENST00000264572	P52306 [Direct mapping] Rap1 GTPase-GDP dissociation stimulator 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration] GO:0043547 [positive regulation of GTPase activity] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:0070062 [extracellular exosome] Show all	516 aa 56.5 kDa	No	0
RAP1GDS1-005 ENSP00000386223 ENST00000408900	P52306 [Direct mapping] Rap1 GTPase-GDP dissociation stimulator 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration] GO:0043547 [positive regulation of GTPase activity] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:0070062 [extracellular exosome] Show all	558 aa 61 kDa	No	0
RAP1GDS1-006 ENSP00000340454 ENST00000339360	P52306 [Direct mapping] Rap1 GTPase-GDP dissociation stimulator 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration] GO:0043547 [positive regulation of GTPase activity] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:0070062 [extracellular exosome] Show all	608 aa 66.4 kDa	No	0
RAP1GDS1-007 ENSP00000407157 ENST00000453712	P52306 [Direct mapping] Rap1 GTPase-GDP dissociation stimulator 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration] GO:0043547 [positive regulation of GTPase activity] GO:0051561 [positive regulation of mitochondrial calcium ion concentration] GO:0070062 [extracellular exosome] Show all	607 aa 66.3 kDa	No	0
RAP1GDS1-008 ENSP00000425992 ENST00000509011	D6RHZ7 [Direct mapping] Rap1 GTPase-GDP dissociation stimulator 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] Show all	122 aa 13.2 kDa	No	0
RAP1GDS1-011 ENSP00000426096 ENST00000508213	D6RHH8 [Direct mapping] Rap1 GTPase-GDP dissociation stimulator 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] Show all	148 aa 16.1 kDa	No	0
RAP1GDS1-016 ENSP00000424324 ENST00000514122	D6RB97 [Direct mapping] Rap1 GTPase-GDP dissociation stimulator 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] Show all	158 aa 17.2 kDa	No	0
RAP1GDS1-017 ENSP00000421599 ENST00000511212	D6REZ0 [Direct mapping] Rap1 GTPase-GDP dissociation stimulator 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	158 aa 16.9 kDa	No	0
RAP1GDS1-020 ENSP00000421482 ENST00000509501	H0Y8M2 [Direct mapping] Rap1 GTPase-GDP dissociation stimulator 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] Show all	253 aa 27.4 kDa	No	0
RAP1GDS1-021 ENSP00000475933 ENST00000514139	U3KQJ4 [Direct mapping] Rap1 GTPase-GDP dissociation stimulator 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	101 aa 10.5 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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