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Cancer cells were generally weakly stained or negative. Several cases of colorectal, breast and prostate cancer showed moderate cytoplasmic immunoreactivity. A few cases of thyroid cancer were strongly stained.
Cancer cells showed weak to moderate cytoplasmic positivity. A few basal cell carcinomas and carcinoids showed strong cytoplasmic staining.
GENE INFORMATION
Gene name
PDE5A
Synonyms
Description
Phosphodiesterase 5A, cGMP-specific (HGNC Symbol)
Entrez gene summary
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004112 [cyclic-nucleotide phosphodiesterase activity] GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0008081 [phosphoric diester hydrolase activity] GO:0010613 [positive regulation of cardiac muscle hypertrophy] GO:0030553 [cGMP binding] GO:0030823 [regulation of cGMP metabolic process] GO:0042130 [negative regulation of T cell proliferation] GO:0043406 [positive regulation of MAP kinase activity] GO:0046068 [cGMP metabolic process] GO:0046069 [cGMP catabolic process] GO:0046872 [metal ion binding] GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity] GO:0055118 [negative regulation of cardiac muscle contraction] GO:0055119 [relaxation of cardiac muscle] GO:0060282 [positive regulation of oocyte development]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
