Tissue expression of TRPC3 - Summary - The Human Protein Atlas

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TRPC3

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TRPC3
Gene description	Transient receptor potential cation channel, subfamily C, member 3
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (smooth muscle)
GTEx:	Tissue enhanced (pituitary gland)
FANTOM5:	Tissue enhanced (pituitary gland, cerebellum)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA037969
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (smooth muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pituitary gland, cerebellum)

GENE INFORMATION
Gene name	TRPC3
Synonyms
Description	Transient receptor potential cation channel, subfamily C, member 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	4
Cytoband	q27
Chromosome location (bp)	121879027 - 121951754
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138741 (version 83.38)
Entrez gene	7222
UniProt	Q13507 (UniProt - Evidence at protein level)
neXtProt	NX_Q13507
Antibodypedia	TRPC3 antibodies

PROTEIN BROWSER

TRPC3-001	TRPC3-002	TRPC3-003	TRPC3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRPC3-001 ENSP00000264811 ENST00000264811	Q13507 [Direct mapping] Short transient receptor potential channel 3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005216 [ion channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006828 [manganese ion transport] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0007602 [phototransduction] GO:0010524 [positive regulation of calcium ion transport into cytosol] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030168 [platelet activation] GO:0033198 [response to ATP] GO:0034220 [ion transmembrane transport] GO:0051480 [cytosolic calcium ion homeostasis] GO:0051592 [response to calcium ion] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0070679 [inositol 1,4,5 trisphosphate binding] GO:1903244 [positive regulation of cardiac muscle hypertrophy in response to stress] Show all	848 aa 97.4 kDa	No	8
TRPC3-002 ENSP00000368966 ENST00000379645	Q13507 [Direct mapping] Short transient receptor potential channel 3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005216 [ion channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006828 [manganese ion transport] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0007602 [phototransduction] GO:0010524 [positive regulation of calcium ion transport into cytosol] GO:0015279 [store-operated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030168 [platelet activation] GO:0033198 [response to ATP] GO:0034220 [ion transmembrane transport] GO:0051480 [cytosolic calcium ion homeostasis] GO:0051592 [response to calcium ion] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0070679 [inositol 1,4,5 trisphosphate binding] GO:1903244 [positive regulation of cardiac muscle hypertrophy in response to stress] Show all	921 aa 105.5 kDa	No	8
TRPC3-003 ENSP00000422214 ENST00000502968	D6R902 [Direct mapping] Short transient receptor potential channel 3 Show all	Predicted intracellular proteins Show all	GO:0005262 [calcium channel activity] GO:0005829 [cytosol] GO:0006828 [manganese ion transport] GO:0016021 [integral component of membrane] GO:0051480 [cytosolic calcium ion homeostasis] GO:0070588 [calcium ion transmembrane transport] Show all	93 aa 10.5 kDa	No	0
TRPC3-005 ENSP00000426899 ENST00000513531	J3QTB0 [Direct mapping] Short transient receptor potential channel 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006811 [ion transport] GO:0006828 [manganese ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0051480 [cytosolic calcium ion homeostasis] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	793 aa 91.2 kDa	No	7

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The Human Protein Atlas

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