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USO1

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GENERAL INFORMATION

Gene name

 USO1

Gene description

 USO1 vesicle transport factor

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the Golgi apparatus. In addition localized to the nucleoli (fibrillar center).

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (validated)

Additional location

 In addition localized to the Nucleoli fibrillar center (supported)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA038282 , HPA038283
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ASSAYS
RNA expression
Human cells
Custom data
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the Golgi apparatus. In addition localized to the nucleoli (fibrillar center).

Main location

 Golgi apparatus (validated)

Additional location

 Nucleoli fibrillar center (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA038282 A-431 Golgi apparatus
HPA038282 Hep G2 Golgi apparatus
HPA038282 U-2 OS No staining    
HPA038283 A-431 Golgi apparatus
HPA038283 Hep G2 Nucleoli fibrillar center
Golgi apparatus
HPA038283 U-2 OS Nucleoli fibrillar center
Golgi apparatus

CUSTOM DATA

 

 

 
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Antibody

Cell line

Assay

Description
HPA038283 U-2 OS Image Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. USO1 localizes to the Golgi apparatus, and is only detected in the cis-Golgi compartment.

MOUSE CELLS

Main location

 Not available

Mouse gene

 ENSMUSG00000029407 (version 83)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location
HPA038282 NIH 3T3 No staining

GENE INFORMATION

Gene name

 USO1 (HGNC Symbol)

Synonyms

 p115, TAP, VDP

Description

 USO1 vesicle transport factor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Chromosome

 4

Cytoband

 q21.1

Chromosome location (bp)

 75724593 - 75814286

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138768 (version 83.38)

Entrez gene

 8615

UniProt

 O60763 (UniProt - Evidence at protein level)

neXtProt

 NX_O60763

Antibodypedia

 USO1 antibodies

PROTEIN BROWSER
USO1-001
USO1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USO1-001
ENSP00000444850
ENST00000514213
O60763 [Direct mapping]
General vesicular transport factor p115
A0A024RDG1 [Target identity:100%; Query identity:100%]
Vesicle docking protein p115, isoform CRA_a
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045056 [transcytosis]
GO:0048208 [COPII vesicle coating]
GO:0048211 [Golgi vesicle docking]
GO:0048280 [vesicle fusion with Golgi apparatus]
GO:0061024 [membrane organization]
GO:0061025 [membrane fusion]
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 962 aa
107.9 kDa 		No 0
USO1-007
ENSP00000264904
ENST00000264904
O60763 [Direct mapping]
General vesicular transport factor p115
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045056 [transcytosis]
GO:0048208 [COPII vesicle coating]
GO:0048211 [Golgi vesicle docking]
GO:0048280 [vesicle fusion with Golgi apparatus]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061024 [membrane organization]
GO:0061025 [membrane fusion]
Show all
 973 aa
109.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.