Cell atlas - CDKL2 - The Human Protein Atlas

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CDKL2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Nucleus

Human cell
	Centrosome
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CDKL2
Gene description	Cyclin-dependent kinase-like 2 (CDC2-related kinase)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & centrosome.
RNA cell category	Cell line enhanced (RPTEC TERT1, A-431)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Centrosome (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA040672
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPTEC TERT1, A-431) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & centrosome.

Main location

Nucleus (supported), Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040672	A-431	Nucleoplasm
	HPA040672	A-431	Centrosome
	HPA040672	U-2 OS	Nucleus
	HPA040672	U-2 OS	Centrosome
	HPA040672	U-251 MG	Nucleus
	HPA040672	U-251 MG	Centrosome

GENE INFORMATION
Gene name	CDKL2 (HGNC Symbol)
Synonyms	KKIAMRE, P56
Description	Cyclin-dependent kinase-like 2 (CDC2-related kinase) (HGNC Symbol)
Entrez gene summary	This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q21.1
Chromosome location (bp)	75578005 - 75630716
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138769 (version 83.38)
Entrez gene	8999
UniProt	Q92772 (UniProt - Evidence at protein level)
neXtProt	NX_Q92772
Antibodypedia	CDKL2 antibodies

PROTEIN BROWSER

CDKL2-001	CDKL2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDKL2-001 ENSP00000412365 ENST00000429927	Q92772 [Direct mapping] Cyclin-dependent kinase-like 2 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007548 [sex differentiation] GO:0051726 [regulation of cell cycle] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	493 aa 56 kDa	No	0
CDKL2-002 ENSP00000306340 ENST00000307465	J3KNE8 [Direct mapping] Cyclin-dependent kinase-like 2 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0006468 [protein phosphorylation] Show all	570 aa 64.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.