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CENPE

CANCER ATLAS

Gene description

 Centromere protein E, 312kDa

Protein class

 Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042294

Tissue

Cancer staining

Protein
expression of
normal tissue
Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue
Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

 Most cancer cells showed moderate nuclear positivity. A few cases of lung, skin, testicular and pancreatic cancers, as well as lymphoma and melanoma showed strong positivity. The majority of prostate and liver cancers were weakly stained or negative.

GENE INFORMATION

Gene name

 CENPE (HGNC Symbol)

Synonyms

 KIF10, PPP1R61

Description

 Centromere protein E, 312kDa (HGNC Symbol)

Entrez gene summary

 Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Nov 2014]

Chromosome

 4

Cytoband

 q24

Chromosome location (bp)

 103105806 - 103198409

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138778 (version 83.38)

Entrez gene

 1062

UniProt

 Q02224 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02224

Antibodypedia

 CENPE antibodies

PROTEIN BROWSER
CENPE-001
CENPE-006
CENPE-007
CENPE-201
CENPE-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CENPE-001
ENSP00000369365
ENST00000380026
Q02224 [Direct mapping]
Centromere-associated protein E
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000940 [condensed chromosome outer kinetochore]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0007059 [chromosome segregation]
GO:0007079 [mitotic chromosome movement towards spindle pole]
GO:0007080 [mitotic metaphase plate congression]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0030496 [midbody]
GO:0043515 [kinetochore binding]
GO:0045860 [positive regulation of protein kinase activity]
GO:0051301 [cell division]
GO:0051315 [attachment of mitotic spindle microtubules to kinetochore]
GO:0051382 [kinetochore assembly]
GO:1990023 [mitotic spindle midzone]
Show all
 2580 aa
301.8 kDa 		No 0
CENPE-006
ENSP00000426023
ENST00000514974
D6RHK2 [Direct mapping]
Kinesin-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 184 aa
20.8 kDa 		No 0
CENPE-007
ENSP00000423981
ENST00000503705
D6RBW0 [Direct mapping]
Kinesin-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016887 [ATPase activity]
Show all
 1126 aa
130.5 kDa 		No 0
CENPE-201
ENSP00000265148
ENST00000265148
Q02224 [Direct mapping]
Centromere-associated protein E
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000778 [condensed nuclear chromosome kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000940 [condensed chromosome outer kinetochore]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0007059 [chromosome segregation]
GO:0007079 [mitotic chromosome movement towards spindle pole]
GO:0007080 [mitotic metaphase plate congression]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0030496 [midbody]
GO:0043515 [kinetochore binding]
GO:0045860 [positive regulation of protein kinase activity]
GO:0051301 [cell division]
GO:0051315 [attachment of mitotic spindle microtubules to kinetochore]
GO:0051382 [kinetochore assembly]
GO:1990023 [mitotic spindle midzone]
Show all
 2701 aa
316.4 kDa 		No 0
CENPE-202
ENSP00000483542
ENST00000611174
A0A087X0P0 [Direct mapping]
Kinesin-like protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005524 [ATP binding]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0007018 [microtubule-based movement]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016887 [ATPase activity]
Show all
 2664 aa
312.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.