Expression of INTS12 in cancer - Summary

CANCER ATLAS

Gene description

Integrator complex subunit 12

Protein class

Cancer-related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035772

GENE INFORMATION
Gene name	INTS12 (HGNC Symbol)
Synonyms	INT12, PHF22, SBBI22
Description	Integrator complex subunit 12 (HGNC Symbol)
Entrez gene summary	INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Chromosome	4
Cytoband	q24
Chromosome location (bp)	105682627 - 105895986
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138785 (version 83.38)
Entrez gene	57117
UniProt	Q96CB8 (UniProt - Evidence at protein level)
neXtProt	NX_Q96CB8
Antibodypedia	INTS12 antibodies

PROTEIN BROWSER

INTS12-001	INTS12-002	INTS12-003	INTS12-005	INTS12-006	INTS12-007	INTS12-008	INTS12-009	INTS12-011	INTS12-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INTS12-001 ENSP00000340737 ENST00000340139	Q96CB8 [Direct mapping] Integrator complex subunit 12 A0A024RDK4 [Target identity:100%; Query identity:100%] Integrator complex subunit 12, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016180 [snRNA processing] GO:0032039 [integrator complex] Show all	462 aa 48.8 kDa	No	0
INTS12-002 ENSP00000378221 ENST00000394735	Q96CB8 [Direct mapping] Integrator complex subunit 12 A0A024RDK4 [Target identity:100%; Query identity:100%] Integrator complex subunit 12, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016180 [snRNA processing] GO:0032039 [integrator complex] Show all	462 aa 48.8 kDa	No	0
INTS12-003 ENSP00000412317 ENST00000420368	C9J0M6 [Direct mapping] Integrator complex subunit 12 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		132 aa 14.4 kDa	No	0
INTS12-005 ENSP00000415433 ENST00000451321	Q96CB8 [Direct mapping] Integrator complex subunit 12 A0A024RDK4 [Target identity:100%; Query identity:100%] Integrator complex subunit 12, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016180 [snRNA processing] GO:0032039 [integrator complex] Show all	462 aa 48.8 kDa	No	0
INTS12-006 ENSP00000396309 ENST00000416543	C9JDP3 [Direct mapping] Integrator complex subunit 12 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		88 aa 9.5 kDa	No	0
INTS12-007 ENSP00000423618 ENST00000503746	E9PGI3 [Direct mapping] Integrator complex subunit 12 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		159 aa 17.4 kDa	No	0
INTS12-008 ENSP00000422048 ENST00000515819	D6R9Y5 [Direct mapping] Integrator complex subunit 12 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		18 aa 1.9 kDa	No	0
INTS12-009 ENSP00000396729 ENST00000433009	C9JDP3 [Direct mapping] Integrator complex subunit 12 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		88 aa 9.5 kDa	No	0
INTS12-011 ENSP00000422856 ENST00000510876	D6R9W3 [Direct mapping] Integrator complex subunit 12 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		57 aa 6.2 kDa	No	0
INTS12-201 ENSP00000481164 ENST00000618810	A0A087WXN4 [Direct mapping] Integrator complex subunit 12 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	444 aa 46.7 kDa	No	0