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Colorectal cancer along with several breast, cervical, endometrial and urothelial cancers showed moderate to strong cytoplasmic immunoreactivity. Remaining malignant cells were in general weakly stained or negative.
Colorectal cancers displayed moderate to strong cytoplasmic and nuclear positivity. Several breast, urothelium, cervix, gastric and endometrial cancers showed moderate cytoplasmic and nuclear positivity. Remaining malignancies were negative.
Strong cytoplasmic and nuclear immunoreactivity was observed in colorectal cancers and a few breast cancers. Remaining malignant tissues were in general weakly stained.
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0008234 [cysteine-type peptidase activity] GO:0012501 [programmed cell death] GO:0030855 [epithelial cell differentiation] GO:0042802 [identical protein binding] GO:0097194 [execution phase of apoptosis] GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis]
