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MAPK8IP3

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GENERAL INFORMATION

Gene name

 MAPK8IP3

Gene description

 Mitogen-activated protein kinase 8 interacting protein 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA041785
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to vesicles.

Main location

 Vesicles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA041785 HeLa Vesicles
Cytokinetic bridge Intensity Intensity
HPA041785 MCF7 Vesicles
HPA041785 U-2 OS Vesicles

MOUSE CELLS

Main location

 Not available

Mouse gene

 ENSMUSG00000024163 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA041785 NIH 3T3 No staining

GENE INFORMATION

Gene name

 MAPK8IP3 (HGNC Symbol)

Synonyms

 JIP3, JSAP1, KIAA1066, syd

Description

 Mitogen-activated protein kinase 8 interacting protein 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 1706183 - 1770317

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138834 (version 83.38)

Entrez gene

 23162

UniProt

 Q9UPT6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UPT6

Antibodypedia

 MAPK8IP3 antibodies

PROTEIN BROWSER
MAPK8IP3-001
MAPK8IP3-007
MAPK8IP3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAPK8IP3-001
ENSP00000250894
ENST00000250894
Q9UPT6 [Direct mapping]
C-Jun-amino-terminal kinase-interacting protein 3
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001701 [in utero embryonic development]
GO:0005078 [MAP-kinase scaffold activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0007254 [JNK cascade]
GO:0007257 [activation of JUN kinase activity]
GO:0007411 [axon guidance]
GO:0007585 [respiratory gaseous exchange]
GO:0008104 [protein localization]
GO:0008432 [JUN kinase binding]
GO:0009791 [post-embryonic development]
GO:0010468 [regulation of gene expression]
GO:0016192 [vesicle-mediated transport]
GO:0019894 [kinesin binding]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030425 [dendrite]
GO:0030673 [axolemma]
GO:0030900 [forebrain development]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0046328 [regulation of JNK cascade]
GO:0048286 [lung alveolus development]
GO:0060425 [lung morphogenesis]
Show all
 1336 aa
147.5 kDa 		No 0
MAPK8IP3-007
ENSP00000348290
ENST00000356010
E9PFH7 [Direct mapping]
C-Jun-amino-terminal kinase-interacting protein 3
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005078 [MAP-kinase scaffold activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007257 [activation of JUN kinase activity]
GO:0008432 [JUN kinase binding]
GO:0016192 [vesicle-mediated transport]
GO:0019894 [kinesin binding]
GO:0030159 [receptor signaling complex scaffold activity]
Show all
 1330 aa
146.7 kDa 		No 0
MAPK8IP3-201
ENSP00000481780
ENST00000610761
A0A087WYG2 [Direct mapping]
C-Jun-amino-terminal kinase-interacting protein 3
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005078 [MAP-kinase scaffold activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007257 [activation of JUN kinase activity]
GO:0008432 [JUN kinase binding]
GO:0016192 [vesicle-mediated transport]
GO:0019894 [kinesin binding]
GO:0030159 [receptor signaling complex scaffold activity]
Show all
 1337 aa
147.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.