Cell atlas - RGS3 - The Human Protein Atlas

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RGS3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitochondria
	Nucleoplasm

Human cell
	Cytosol
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RGS3
Gene description	Regulator of G-protein signaling 3
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol & mitochondria.
RNA cell category	Cell line enhanced (HDLM-2, BJ hTERT+)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Additional location	In addition localized to the Mitochondria (approved), Cytosol (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. CAB032507 , HPA041109
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, BJ hTERT+) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol & mitochondria.

Main location

Nucleoplasm (validated)

Additional location

Mitochondria (approved), Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
CAB032507	A-431	Nucleoplasm
CAB032507	A-431	Mitochondria
CAB032507	U-2 OS	Nucleoplasm
CAB032507	U-2 OS	Mitochondria
CAB032507	U-251 MG	Nucleoplasm
CAB032507	U-251 MG	Mitochondria
HPA041109	CACO-2	Nucleoplasm
HPA041109	CACO-2	Cytosol
HPA041109	MCF7	Nucleoplasm
HPA041109	MCF7	Cytosol
HPA041109	U-2 OS	Nucleoplasm
HPA041109	U-2 OS	Cytosol

GENE INFORMATION
Gene name	RGS3 (HGNC Symbol)
Synonyms	C2PA, FLJ20370, PDZ-RGS3
Description	Regulator of G-protein signaling 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]
Chromosome	9
Cytoband	q32
Chromosome location (bp)	113444731 - 113597743
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138835 (version 83.38)
Entrez gene	5998
UniProt	P49796 (UniProt - Evidence at protein level)
neXtProt	NX_P49796
Antibodypedia	RGS3 antibodies

PROTEIN BROWSER

RGS3-001	RGS3-002	RGS3-003	RGS3-006	RGS3-007	RGS3-008	RGS3-013	RGS3-017	RGS3-019	RGS3-026	RGS3-030	RGS3-201	RGS3-202	RGS3-203	RGS3-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RGS3-001 ENSP00000363255 ENST00000374140	P49796 [Direct mapping] Regulator of G-protein signaling 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0043547 [positive regulation of GTPase activity] Show all	1198 aa 132.3 kDa	No	0
RGS3-002 ENSP00000312844 ENST00000317613	P49796 [Direct mapping] Regulator of G-protein signaling 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0043547 [positive regulation of GTPase activity] Show all	602 aa 67.3 kDa	No	0
RGS3-003 ENSP00000417994 ENST00000467805	C9J582 [Direct mapping] Regulator of G-protein-signaling 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] Show all	247 aa 26.4 kDa	No	0
RGS3-006 ENSP00000340284 ENST00000343817	P49796 [Direct mapping] Regulator of G-protein signaling 3 A0A024R841 [Target identity:100%; Query identity:100%] Regulator of G-protein signalling 3, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0043547 [positive regulation of GTPase activity] Show all	917 aa 100.9 kDa	No	0
RGS3-007 ENSP00000363249 ENST00000374134	P49796 [Direct mapping] Regulator of G-protein signaling 3 A0A024R831 [Target identity:100%; Query identity:100%] Regulator of G-protein signalling 3, isoform CRA_e Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0043547 [positive regulation of GTPase activity] Show all	519 aa 56.6 kDa	No	0
RGS3-008 ENSP00000436168 ENST00000462403	P49796 [Direct mapping] Regulator of G-protein signaling 3 A0A024R833 [Target identity:100%; Query identity:100%] Regulator of G-protein signalling 3, isoform CRA_b Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0043547 [positive regulation of GTPase activity] Show all	311 aa 35.1 kDa	No	0
RGS3-013 ENSP00000363251 ENST00000374136	Q5VXC0 [Direct mapping] Regulator of G-protein-signaling 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] Show all	340 aa 37.5 kDa	No	0
RGS3-017 ENSP00000420356 ENST00000462143	P49796 [Direct mapping] Regulator of G-protein signaling 3 A0A024R831 [Target identity:100%; Query identity:100%] Regulator of G-protein signalling 3, isoform CRA_e Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0043547 [positive regulation of GTPase activity] Show all	519 aa 56.6 kDa	No	0
RGS3-019 ENSP00000417866 ENST00000471324	C9J6G2 [Direct mapping] Regulator of G-protein-signaling 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] Show all	74 aa 7.7 kDa	No	0
RGS3-026 ENSP00000418898 ENST00000496113	H7C539 [Direct mapping] Regulator of G-protein-signaling 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] Show all	214 aa 23.3 kDa	No	0
RGS3-030 ENSP00000479017 ENST00000620489	A0A087WUY2 [Direct mapping] Regulator of G-protein-signaling 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] Show all	192 aa 22.4 kDa	No	0
RGS3-201 ENSP00000343359 ENST00000342620	H7BXY1 [Direct mapping] Regulator of G-protein signalling 3, isoform CRA_i; Regulator of G-protein-signaling 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] Show all	168 aa 19.5 kDa	No	0
RGS3-202 ENSP00000259406 ENST00000350696	P49796 [Direct mapping] Regulator of G-protein signaling 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0043547 [positive regulation of GTPase activity] Show all	1198 aa 132.3 kDa	No	0
RGS3-203 ENSP00000378141 ENST00000394646	P49796 [Direct mapping] Regulator of G-protein signaling 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0043547 [positive regulation of GTPase activity] Show all	591 aa 66.5 kDa	No	0
RGS3-204 ENSP00000482612 ENST00000613049	P49796 [Direct mapping] Regulator of G-protein signaling 3 A0A024R833 [Target identity:100%; Query identity:100%] Regulator of G-protein signalling 3, isoform CRA_b Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0043547 [positive regulation of GTPase activity] Show all	311 aa 35.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.