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ETV6

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GENERAL INFORMATION

Gene name

 ETV6

Gene description

 Ets variant 6

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoli. In addition localized to the cytosol.

RNA cell category

 Cell line enhanced (HDLM-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli (validated)

Additional location

 In addition localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA000264
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoli. In addition localized to the cytosol.

Main location

 Nucleoli (validated)

Additional location

 Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA000264 A-431 Nucleoli
Cytosol
HPA000264 U-2 OS Nucleoli
Cytosol
HPA000264 U-251 MG Nucleoli
Cytosol

GENE INFORMATION

Gene name

 ETV6 (HGNC Symbol)

Synonyms

 TEL

Description

 Ets variant 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]

Chromosome

 12

Cytoband

 p13.2

Chromosome location (bp)

 11649854 - 11895402

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139083 (version 83.38)

Entrez gene

 2120

UniProt

 P41212 (UniProt - Evidence at protein level)

neXtProt

 NX_P41212

Antibodypedia

 ETV6 antibodies

PROTEIN BROWSER
ETV6-001
ETV6-004
ETV6-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ETV6-001
ENSP00000379658
ENST00000396373
P41212 [Direct mapping]
Transcription factor ETV6
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0019904 [protein domain specific binding]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0071425 [hematopoietic stem cell proliferation]
Show all
 452 aa
53 kDa 		No 0
ETV6-004
ENSP00000441463
ENST00000545027
H0YG25 [Direct mapping]
Transcription factor ETV6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 88 aa
10.3 kDa 		No 0
ETV6-005
ENSP00000266427
ENST00000266427
J3KN52 [Direct mapping]
Transcription factor ETV6
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 50 aa
5.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.