Expression of YARS2 in cancer - Summary

CANCER ATLAS

Gene description

Tyrosyl-tRNA synthetase 2, mitochondrial

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA038721	HPA057610

GENE INFORMATION
Gene name	YARS2 (HGNC Symbol)
Synonyms	CGI-04, FLJ13995, mt-TyrRS
Description	Tyrosyl-tRNA synthetase 2, mitochondrial (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011]
Chromosome	12
Cytoband	p11.21
Chromosome location (bp)	32727490 - 32755902
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139131 (version 83.38)
Entrez gene	51067
UniProt	Q9Y2Z4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2Z4
Antibodypedia	YARS2 antibodies

PROTEIN BROWSER

YARS2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
YARS2-001 ENSP00000320658 ENST00000324868	Q9Y2Z4 [Direct mapping] Tyrosine--tRNA ligase, mitochondrial Show all	Enzymes ENZYME proteins Ligase THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004831 [tyrosine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006412 [translation] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006437 [tyrosyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0042803 [protein homodimerization activity] GO:0043039 [tRNA aminoacylation] GO:0044822 [poly(A) RNA binding] GO:0070184 [mitochondrial tyrosyl-tRNA aminoacylation] GO:0072545 [tyrosine binding] Show all	477 aa 53.2 kDa	No	0