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PIK3C2G

GENERAL INFORMATION

Gene name

 PIK3C2G

Gene description

 Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (epididymis, stomach)
GTEx:Tissue enhanced (stomach)
FANTOM5:Tissue enhanced (seminal vesicle, epididymis)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (epididymis, stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (stomach)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (seminal vesicle, epididymis)

GENE INFORMATION

Gene name

 PIK3C2G

Synonyms

Description

 Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Chromosome

 12

Cytoband

 p12.3

Chromosome location (bp)

 18247614 - 18648416

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139144 (version 83.38)

Entrez gene

 5288

UniProt

 O75747 (UniProt - Evidence at protein level)

neXtProt

 NX_O75747

Antibodypedia

 PIK3C2G antibodies

PROTEIN BROWSER
PIK3C2G-002
PIK3C2G-004
PIK3C2G-005
PIK3C2G-201
PIK3C2G-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIK3C2G-002
ENSP00000266497
ENST00000266497
O75747 [Direct mapping]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Show all
GO:0002250 [adaptive immune response]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006954 [inflammatory response]
GO:0008150 [biological_process]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016303 [1-phosphatidylinositol-3-kinase activity]
GO:0016307 [phosphatidylinositol phosphate kinase activity]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030168 [platelet activation]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0035091 [phosphatidylinositol binding]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0060326 [cell chemotaxis]
Show all
 1445 aa
165.7 kDa 		No 0
PIK3C2G-004
ENSP00000443850
ENST00000535651
F5H7Y7 [Direct mapping]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Show all
Predicted intracellular proteins
Show all
GO:0002250 [adaptive immune response]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016303 [1-phosphatidylinositol-3-kinase activity]
GO:0030168 [platelet activation]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0060326 [cell chemotaxis]
Show all
 583 aa
67 kDa 		No 0
PIK3C2G-005
ENSP00000479145
ENST00000536967
A0A087WV31 [Direct mapping]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Show all
Predicted intracellular proteins
Show all
GO:0002250 [adaptive immune response]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016303 [1-phosphatidylinositol-3-kinase activity]
GO:0030168 [platelet activation]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0060326 [cell chemotaxis]
Show all
 187 aa
21.1 kDa 		No 0
PIK3C2G-201
ENSP00000404845
ENST00000433979
O75747 [Direct mapping]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006954 [inflammatory response]
GO:0008150 [biological_process]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016303 [1-phosphatidylinositol-3-kinase activity]
GO:0016307 [phosphatidylinositol phosphate kinase activity]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030168 [platelet activation]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0035091 [phosphatidylinositol binding]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0060326 [cell chemotaxis]
Show all
 1445 aa
165.7 kDa 		No 0
PIK3C2G-202
ENSP00000445381
ENST00000538779
F5H369 [Direct mapping]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Show all
Predicted intracellular proteins
Show all
GO:0002250 [adaptive immune response]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016303 [1-phosphatidylinositol-3-kinase activity]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030168 [platelet activation]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0035091 [phosphatidylinositol binding]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0060326 [cell chemotaxis]
Show all
 1486 aa
170.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.