Tissue expression of SLCO1C1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLCO1C1
Gene description	Solute carrier organic anion transporter family, member 1C1
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (caudate, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5:	Tissue enhanced (retina, caudate, hippocampus)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (retina, caudate, hippocampus)

GENE INFORMATION
Gene name	SLCO1C1 (HGNC Symbol)
Synonyms	OATP-F, OATP1, OATP1C1, SLC21A14
Description	Solute carrier organic anion transporter family, member 1C1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Chromosome	12
Cytoband	p12.2
Chromosome location (bp)	20695355 - 20753386
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000139155 (version 83.38)
Entrez gene	53919
UniProt	Q9NYB5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NYB5
Antibodypedia	SLCO1C1 antibodies

PROTEIN BROWSER

SLCO1C1-001	SLCO1C1-002	SLCO1C1-004	SLCO1C1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLCO1C1-001 ENSP00000266509 ENST00000266509	Q9NYB5 [Direct mapping] Solute carrier organic anion transporter family member 1C1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008206 [bile acid metabolic process] GO:0015125 [bile acid transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015721 [bile acid and bile salt transport] GO:0016020 [membrane] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	712 aa 78.7 kDa	No	>9
SLCO1C1-002 ENSP00000438665 ENST00000540354	Q9NYB5 [Direct mapping] Solute carrier organic anion transporter family member 1C1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008206 [bile acid metabolic process] GO:0015125 [bile acid transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015721 [bile acid and bile salt transport] GO:0016020 [membrane] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	663 aa 73.3 kDa	No	>9
SLCO1C1-004 ENSP00000444527 ENST00000545102	Q9NYB5 [Direct mapping] Solute carrier organic anion transporter family member 1C1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008206 [bile acid metabolic process] GO:0015125 [bile acid transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015721 [bile acid and bile salt transport] GO:0016020 [membrane] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	612 aa 67.7 kDa	No	7
SLCO1C1-010 ENSP00000444149 ENST00000545604	Q9NYB5 [Direct mapping] Solute carrier organic anion transporter family member 1C1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008206 [bile acid metabolic process] GO:0015125 [bile acid transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015721 [bile acid and bile salt transport] GO:0016020 [membrane] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	730 aa 80.7 kDa	No	>9