Expression of ETNK1 in cancer - Summary

CANCER ATLAS

Gene description

Ethanolamine kinase 1

Protein class

Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Pancreatic cancer

STAINING SUMMARY

HPA010712	HPA029407

GENE INFORMATION
Gene name	ETNK1 (HGNC Symbol)
Synonyms	EKI, EKI1
Description	Ethanolamine kinase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine synthesis pathway. This cytosolic enzyme is specific for ethanolamine and exhibits negligible kinase activity on choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p12.1
Chromosome location (bp)	22625075 - 22690665
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139163 (version 83.38)
Entrez gene	55500
UniProt	Q9HBU6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HBU6
Antibodypedia	ETNK1 antibodies

PROTEIN BROWSER

ETNK1-001	ETNK1-002	ETNK1-005	ETNK1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ETNK1-001 ENSP00000266517 ENST00000266517	Q9HBU6 [Direct mapping] Ethanolamine kinase 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004305 [ethanolamine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0006646 [phosphatidylethanolamine biosynthetic process] GO:0016020 [membrane] GO:0016310 [phosphorylation] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	452 aa 51 kDa	No	2
ETNK1-002 ENSP00000334041 ENST00000335148	Q9HBU6 [Direct mapping] Ethanolamine kinase 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004305 [ethanolamine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0006646 [phosphatidylethanolamine biosynthetic process] GO:0016020 [membrane] GO:0016310 [phosphorylation] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	258 aa 28 kDa	No	1
ETNK1-005 ENSP00000439614 ENST00000545979	H0YFP7 [Direct mapping] Ethanolamine kinase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	82 aa 8.9 kDa	No	0
ETNK1-006 ENSP00000446292 ENST00000538218	H0YH69 [Direct mapping] Ethanolamine kinase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	425 aa 47.6 kDa	No	1