Tissue expression of KLRG1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KLRG1
Gene description	Killer cell lectin-like receptor subfamily G, member 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (spleen)
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	KLRG1 (HGNC Symbol)
Synonyms	2F1, CLEC15A, MAFA, MAFA-L
Description	Killer cell lectin-like receptor subfamily G, member 1 (HGNC Symbol)
Entrez gene summary	Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	8950044 - 9010760
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139187 (version 83.38)
Entrez gene	10219
UniProt	Q96E93 (UniProt - Evidence at protein level)
neXtProt	NX_Q96E93
Antibodypedia	KLRG1 antibodies

PROTEIN BROWSER

KLRG1-001	KLRG1-002	KLRG1-004	KLRG1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLRG1-001 ENSP00000349477 ENST00000356986	Q96E93 [Direct mapping] Killer cell lectin-like receptor subfamily G member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0006968 [cellular defense response] GO:0007166 [cell surface receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] Show all	189 aa 21.2 kDa	No	1
KLRG1-002 ENSP00000266551 ENST00000266551	Q96E93 [Direct mapping] Killer cell lectin-like receptor subfamily G member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0006968 [cellular defense response] GO:0007166 [cell surface receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] Show all	195 aa 21.8 kDa	No	1
KLRG1-004 ENSP00000445627 ENST00000539240	F5H207 [Direct mapping] Killer cell lectin-like receptor subfamily G member 1 Show all	Predicted intracellular proteins Show all		81 aa 9.5 kDa	No	0
KLRG1-006 ENSP00000443658 ENST00000543895	F5H8E3 [Direct mapping] Killer cell lectin-like receptor subfamily G member 1 Show all	Predicted intracellular proteins Show all		80 aa 9.4 kDa	No	0