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Moderate to strong nuclear immunoreactivity was displayed in cancer tissues. Additional luminal membranous staining was observed in colorectal cancers.
GENE INFORMATION
Gene name
ANP32D (HGNC Symbol)
Synonyms
PP32R2
Description
Acidic (leucine-rich) nuclear phosphoprotein 32 family, member D (HGNC Symbol)
Entrez gene summary
Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is absent in the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008]