Cell atlas - PHLDA1 - The Human Protein Atlas

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PHLDA1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	PHLDA1
Gene description	Pleckstrin homology-like domain, family A, member 1
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA063520
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli.

Main location

Nucleoli (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA063520	PC-3	Nucleus
	HPA063520	PC-3	Nucleoli
	HPA063520	U-2 OS	Nucleoli

GENE INFORMATION
Gene name	PHLDA1 (HGNC Symbol)
Synonyms	DT1P1B11, PHRIP, TDAG51
Description	Pleckstrin homology-like domain, family A, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q21.2
Chromosome location (bp)	76025447 - 76033932
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139289 (version 83.38)
Entrez gene	22822
UniProt	Q8WV24 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WV24
Antibodypedia	PHLDA1 antibodies

PROTEIN BROWSER

PHLDA1-001	PHLDA1-003	PHLDA1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PHLDA1-001 ENSP00000266671 ENST00000266671	Q8WV24 [Direct mapping] Pleckstrin homology-like domain family A member 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0021879 [forebrain neuron differentiation] GO:0030659 [cytoplasmic vesicle membrane] GO:0043065 [positive regulation of apoptotic process] GO:0045210 [FasL biosynthetic process] Show all	401 aa 45 kDa	No	0
PHLDA1-003 ENSP00000473593 ENST00000602540	R4GND3 [Direct mapping] Pleckstrin homology-like domain family A member 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] Show all	260 aa 29.7 kDa	No	0
PHLDA1-201 ENSP00000480767 ENST00000619060	Q8WV24 [Direct mapping] Pleckstrin homology-like domain family A member 1 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0030659 [cytoplasmic vesicle membrane] Show all	401 aa 45 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.