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DUSP6

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GENERAL INFORMATION

Gene name

 DUSP6

Gene description

 Dual specificity phosphatase 6

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Cell line enhanced (AN3-CA)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (uncertain)

Additional location

 In addition localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Uncertain based on 1 antibody.
HPA053188
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AN3-CA)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (uncertain)

Additional location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA053188 CACO-2 Nucleoplasm
Cytosol
HPA053188 PC-3 Nucleoplasm
Cytosol
HPA053188 U-2 OS Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 DUSP6 (HGNC Symbol)

Synonyms

 MKP-3, PYST1

Description

 Dual specificity phosphatase 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]

Chromosome

 12

Cytoband

 q21.33

Chromosome location (bp)

 89347232 - 89353271

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139318 (version 83.38)

Entrez gene

 1848

UniProt

 Q16828 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16828

Antibodypedia

 DUSP6 antibodies

PROTEIN BROWSER
DUSP6-001
DUSP6-002
DUSP6-003
DUSP6-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DUSP6-001
ENSP00000279488
ENST00000279488
Q16828 [Direct mapping]
Dual specificity protein phosphatase 6
A0A024RBC1 [Target identity:100%; Query identity:100%]
Dual specificity protein phosphatase
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000188 [inactivation of MAPK activity]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009953 [dorsal/ventral pattern formation]
GO:0010033 [response to organic substance]
GO:0010942 [positive regulation of cell death]
GO:0014070 [response to organic cyclic compound]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity]
GO:0030154 [cell differentiation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway]
GO:0042493 [response to drug]
GO:0042663 [regulation of endodermal cell fate specification]
GO:0043065 [positive regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0051409 [response to nitrosative stress]
GO:0060420 [regulation of heart growth]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070848 [response to growth factor]
Show all
 381 aa
42.3 kDa 		No 0
DUSP6-002
ENSP00000307835
ENST00000308385
Q16828 [Direct mapping]
Dual specificity protein phosphatase 6
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000188 [inactivation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009953 [dorsal/ventral pattern formation]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway]
GO:0042663 [regulation of endodermal cell fate specification]
GO:0043065 [positive regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0051409 [response to nitrosative stress]
GO:0060420 [regulation of heart growth]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
Show all
 235 aa
26.5 kDa 		No 0
DUSP6-003
ENSP00000446858
ENST00000548755
F8VZA4 [Direct mapping]
Dual-specificity protein phosphatase 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0009953 [dorsal/ventral pattern formation]
GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway]
GO:0042663 [regulation of endodermal cell fate specification]
GO:0060420 [regulation of heart growth]
Show all
 117 aa
13.2 kDa 		No 0
DUSP6-005
ENSP00000449838
ENST00000547291
F8VW29 [Direct mapping]
Dual-specificity protein phosphatase 6
Show all
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000188 [inactivation of MAPK activity]
GO:0006470 [protein dephosphorylation]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0009953 [dorsal/ventral pattern formation]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity]
GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway]
GO:0042663 [regulation of endodermal cell fate specification]
GO:0060420 [regulation of heart growth]
Show all
 256 aa
28.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.