Tissue expression of LUM - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	LUM
Gene description	Lumican
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (gallbladder)
GTEx:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (gallbladder)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	LUM (HGNC Symbol)
Synonyms	LDC, SLRR2D
Description	Lumican (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q21.33
Chromosome location (bp)	91102629 - 91111831
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139329 (version 83.38)
Entrez gene	4060
UniProt	P51884 (UniProt - Evidence at protein level)
neXtProt	NX_P51884
Antibodypedia	LUM antibodies

PROTEIN BROWSER

LUM-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LUM-001 ENSP00000266718 ENST00000266718	P51884 [Direct mapping] Lumican Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005583 [fibrillar collagen trimer] GO:0005615 [extracellular space] GO:0005796 [Golgi lumen] GO:0005975 [carbohydrate metabolic process] GO:0007601 [visual perception] GO:0014070 [response to organic cyclic compound] GO:0018146 [keratan sulfate biosynthetic process] GO:0030198 [extracellular matrix organization] GO:0030199 [collagen fibril organization] GO:0030203 [glycosaminoglycan metabolic process] GO:0031012 [extracellular matrix] GO:0032914 [positive regulation of transforming growth factor beta1 production] GO:0042339 [keratan sulfate metabolic process] GO:0042340 [keratan sulfate catabolic process] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051216 [cartilage development] GO:0070062 [extracellular exosome] GO:0070848 [response to growth factor] Show all	338 aa 38.4 kDa	Yes	0