Cell atlas - AMDHD1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	AMDHD1
Gene description	Amidohydrolase domain containing 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the actin filaments & focal adhesion sites.
RNA cell category	Cell line enhanced (HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Additional location	In addition localized to the Actin filaments (approved), Focal adhesion sites (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA039720
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the actin filaments & focal adhesion sites.

Main location

Plasma membrane (approved)

Additional location

Actin filaments (approved), Focal adhesion sites (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA039720	Hep G2	Plasma membrane
HPA039720	U-2 OS	Plasma membrane
HPA039720	U-2 OS	Actin filaments
HPA039720	U-251 MG	Focal adhesion sites

GENE INFORMATION
Gene name	AMDHD1 (HGNC Symbol)
Synonyms	MGC35366
Description	Amidohydrolase domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q23.1
Chromosome location (bp)	95943293 - 95968716
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139344 (version 83.38)
Entrez gene	144193
UniProt	Q96NU7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96NU7
Antibodypedia	AMDHD1 antibodies

PROTEIN BROWSER

AMDHD1-001	AMDHD1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMDHD1-001 ENSP00000266736 ENST00000266736	Q96NU7 [Direct mapping] Probable imidazolonepropionase Show all	Enzymes ENZYME proteins Hydrolases Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006548 [histidine catabolic process] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] GO:0016812 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides] GO:0019556 [histidine catabolic process to glutamate and formamide] GO:0019557 [histidine catabolic process to glutamate and formate] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050480 [imidazolonepropionase activity] Show all	426 aa 46.7 kDa	No	0
AMDHD1-004 ENSP00000448918 ENST00000553023		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		6 aa 0.6 kDa	No	0