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GIT2

GENERAL INFORMATION

Gene name

 GIT2

Gene description

 G protein-coupled receptor kinase interacting ArfGAP 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB004681
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GIT2 (HGNC Symbol)

Synonyms

 KIAA0148

Description

 G protein-coupled receptor kinase interacting ArfGAP 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]

Chromosome

 12

Cytoband

 q24.11

Chromosome location (bp)

 109929792 - 109996389

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139436 (version 83.38)

Entrez gene

 9815

UniProt

 Q14161 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14161

Antibodypedia

 GIT2 antibodies

PROTEIN BROWSER
GIT2-001
GIT2-004
GIT2-005
GIT2-006
GIT2-007
GIT2-008
GIT2-010
GIT2-011
GIT2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GIT2-001
ENSP00000347464
ENST00000355312
Q14161 [Direct mapping]
ARF GTPase-activating protein GIT2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005925 [focal adhesion]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0032403 [protein complex binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0048266 [behavioral response to pain]
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 759 aa
84.5 kDa 		No 0
GIT2-004
ENSP00000354282
ENST00000361006
Q14161 [Direct mapping]
ARF GTPase-activating protein GIT2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005925 [focal adhesion]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
Show all
 729 aa
81.3 kDa 		No 0
GIT2-005
ENSP00000473637
ENST00000550186
R4GNG3 [Direct mapping]
ARF GTPase-activating protein GIT2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 641 aa
71.5 kDa 		No 0
GIT2-006
ENSP00000450348
ENST00000547815
Q14161 [Direct mapping]
ARF GTPase-activating protein GIT2
Q6FI58 [Target identity:100%; Query identity:100%]
G protein-coupled receptor kinase-interactor 2 isoform 4; G protein-coupled receptor kinase-interactor 2 isoform 4 variant; GIT2 protein
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005925 [focal adhesion]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
Show all
 471 aa
52.6 kDa 		No 0
GIT2-007
ENSP00000323833
ENST00000320063
F8W822 [Direct mapping]
ARF GTPase-activating protein GIT2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
Show all
 421 aa
47 kDa 		No 0
GIT2-008
ENSP00000447465
ENST00000553118
Q14161 [Direct mapping]
ARF GTPase-activating protein GIT2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005925 [focal adhesion]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
Show all
 631 aa
70.2 kDa 		No 0
GIT2-010
ENSP00000391813
ENST00000457474
Q14161 [Direct mapping]
ARF GTPase-activating protein GIT2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005925 [focal adhesion]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
Show all
 681 aa
76.1 kDa 		No 0
GIT2-011
ENSP00000448832
ENST00000551209
F8VXI9 [Direct mapping]
ARF GTPase-activating protein GIT2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
Show all
 708 aa
78.9 kDa 		No 0
GIT2-201
ENSP00000346585
ENST00000354574
F8WAK2 [Direct mapping]
ARF GTPase-activating protein GIT2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
Show all
 681 aa
76 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.