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NPFF

GENERAL INFORMATION

Gene name

 NPFF

Gene description

 Neuropeptide FF-amide peptide precursor

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (epididymis)
FANTOM5:Tissue enriched (epididymis)

Protein evidence

 Evidence at transcript level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (epididymis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (epididymis)

GENE INFORMATION

Gene name

 NPFF (HGNC Symbol)

Synonyms

 FMRFAL

Description

 Neuropeptide FF-amide peptide precursor (HGNC Symbol)

Entrez gene summary

 FMFRamide-related protein precursor plays a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. FMRFAL encodes a preproprotein which is cleaved to form two active peptides with similar function. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 53506690 - 53507638

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000139574 (version 83.38)

Entrez gene

 8620

UniProt

 O15130 (UniProt - Inferred from homology)

neXtProt

 NX_O15130

Antibodypedia

 NPFF antibodies

PROTEIN BROWSER
NPFF-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NPFF-001
ENSP00000267017
ENST00000267017
O15130 [Direct mapping]
Pro-FMRFamide-related neuropeptide FF Neuropeptide SF Neuropeptide FF Neuropeptide AF
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0002438 [acute inflammatory response to antigenic stimulus]
GO:0003254 [regulation of membrane depolarization]
GO:0005102 [receptor binding]
GO:0005184 [neuropeptide hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0010459 [negative regulation of heart rate]
GO:0021510 [spinal cord development]
GO:0030103 [vasopressin secretion]
GO:0030425 [dendrite]
GO:0031982 [vesicle]
GO:0032099 [negative regulation of appetite]
GO:0042493 [response to drug]
GO:0043204 [perikaryon]
GO:0043278 [response to morphine]
GO:0043679 [axon terminus]
GO:0045777 [positive regulation of blood pressure]
GO:0046676 [negative regulation of insulin secretion]
GO:0051930 [regulation of sensory perception of pain]
GO:0060079 [excitatory postsynaptic potential]
GO:0060135 [maternal process involved in female pregnancy]
GO:0070253 [somatostatin secretion]
Show all
 113 aa
12.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.