Expression of CSAD in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Cysteine sulfinic acid decarboxylase

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039487

GENE INFORMATION
Gene name	CSAD (HGNC Symbol)
Synonyms	CSD, PCAP
Description	Cysteine sulfinic acid decarboxylase (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the group 2 decarboxylase family. A similar protein in rodents plays a role in multiple biological processes as the rate-limiting enzyme in taurine biosynthesis, catalyzing the decarboxylation of cysteinesulfinate to hypotaurine. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	53157663 - 53180909
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139631 (version 83.38)
Entrez gene	51380
UniProt	Q9Y600 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y600
Antibodypedia	CSAD antibodies

PROTEIN BROWSER

CSAD-002	CSAD-003	CSAD-004	CSAD-005	CSAD-007	CSAD-009	CSAD-017	CSAD-019	CSAD-020	CSAD-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CSAD-002 ENSP00000369175 ENST00000379846	Q9Y600 [Direct mapping] Cysteine sulfinic acid decarboxylase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000096 [sulfur amino acid metabolic process] GO:0000098 [sulfur amino acid catabolic process] GO:0004782 [sulfinoalanine decarboxylase activity] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042412 [taurine biosynthetic process] GO:0044281 [small molecule metabolic process] Show all	346 aa 38.2 kDa	No	0
CSAD-003 ENSP00000369179 ENST00000379850	J3KPG9 [Direct mapping] Cysteine sulfinic acid decarboxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	519 aa 57.6 kDa	No	0
CSAD-004 ENSP00000267085 ENST00000267085	Q9Y600 [Direct mapping] Cysteine sulfinic acid decarboxylase Show all	Enzymes ENZYME proteins Lyases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000096 [sulfur amino acid metabolic process] GO:0000098 [sulfur amino acid catabolic process] GO:0004782 [sulfinoalanine decarboxylase activity] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042412 [taurine biosynthetic process] GO:0044281 [small molecule metabolic process] Show all	520 aa 58 kDa	Yes	0
CSAD-005 ENSP00000401078 ENST00000424990	C9JTU8 [Direct mapping] Cysteine sulfinic acid decarboxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	146 aa 16.2 kDa	No	0
CSAD-007 ENSP00000457264 ENST00000498635	H3BTP4 [Direct mapping] Cysteine sulfinic acid decarboxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	129 aa 14.4 kDa	No	0
CSAD-009 ENSP00000415314 ENST00000437073	E9PFW9 [Direct mapping] Cysteine sulfinic acid decarboxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	163 aa 17.9 kDa	No	0
CSAD-017 ENSP00000415485 ENST00000444623	Q9Y600 [Direct mapping] Cysteine sulfinic acid decarboxylase A0A024RAX7 [Target identity:100%; Query identity:100%] Cysteine sulfinic acid decarboxylase, isoform CRA_a Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000096 [sulfur amino acid metabolic process] GO:0000098 [sulfur amino acid catabolic process] GO:0004782 [sulfinoalanine decarboxylase activity] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042412 [taurine biosynthetic process] GO:0044281 [small molecule metabolic process] Show all	493 aa 55 kDa	No	0
CSAD-019 ENSP00000410648 ENST00000453446	Q9Y600 [Direct mapping] Cysteine sulfinic acid decarboxylase A0A024RAX7 [Target identity:100%; Query identity:100%] Cysteine sulfinic acid decarboxylase, isoform CRA_a Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000096 [sulfur amino acid metabolic process] GO:0000098 [sulfur amino acid catabolic process] GO:0004782 [sulfinoalanine decarboxylase activity] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042412 [taurine biosynthetic process] GO:0044281 [small molecule metabolic process] Show all	493 aa 55 kDa	No	0
CSAD-020 ENSP00000449373 ENST00000548698	F8VV11 [Direct mapping] Cysteine sulfinic acid decarboxylase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	135 aa 14.1 kDa	No	0
CSAD-201 ENSP00000369172 ENST00000379843	Q9Y602 [Direct mapping] Cysteine sulfinic acid decarboxylase; Cysteine sulfinic acid decarboxylase, isoform CRA_c; Cysteine sulfinic acid decarboxylase-related protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	267 aa 30.3 kDa	No	0