Expression of LPAR6 in cancer - Summary

CANCER ATLAS

Gene description

Lysophosphatidic acid receptor 6

Protein class

Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA028934

GENE INFORMATION
Gene name	LPAR6 (HGNC Symbol)
Synonyms	P2RY5, P2Y5
Description	Lysophosphatidic acid receptor 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Chromosome	13
Cytoband	q14.2
Chromosome location (bp)	48389567 - 48444704
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139679 (version 83.38)
Entrez gene	10161
UniProt	P43657 (UniProt - Evidence at protein level)
neXtProt	NX_P43657
Antibodypedia	LPAR6 antibodies

PROTEIN BROWSER

LPAR6-001	LPAR6-003	LPAR6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LPAR6-001 ENSP00000344353 ENST00000345941	P43657 [Direct mapping] Lysophosphatidic acid receptor 6 A0A024RDT2 [Target identity:100%; Query identity:100%] HCG30749, isoform CRA_a Show all	G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	344 aa 39.4 kDa	No	7
LPAR6-003 ENSP00000367691 ENST00000378434	P43657 [Direct mapping] Lysophosphatidic acid receptor 6 A0A024RDT2 [Target identity:100%; Query identity:100%] HCG30749, isoform CRA_a Show all	G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	344 aa 39.4 kDa	No	7
LPAR6-201 ENSP00000482660 ENST00000620633	P43657 [Direct mapping] Lysophosphatidic acid receptor 6 A0A024RDT2 [Target identity:100%; Query identity:100%] HCG30749, isoform CRA_a Show all	G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	344 aa 39.4 kDa	No	7