Cell atlas - DIAPH3 - The Human Protein Atlas

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DIAPH3

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules
	Plasma membrane

Human cell
	Microtubules
	Plasma Membrane

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GENERAL INFORMATION
Gene name	DIAPH3
Gene description	Diaphanous-related formin 3
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & microtubules.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported), Microtubules (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA032151
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & microtubules.

Main location

Plasma membrane (supported), Microtubules (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA032151	A-431	Plasma membrane
	HPA032151	A-431	Microtubules
	HPA032151	U-2 OS	Plasma membrane
	HPA032151	U-2 OS	Microtubules
	HPA032151	U-251 MG	Plasma membrane
	HPA032151	U-251 MG	Microtubules

GENE INFORMATION
Gene name	DIAPH3 (HGNC Symbol)
Synonyms	AN, AUNA1, DRF3, FLJ34705, NSDAN
Description	Diaphanous-related formin 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Chromosome	13
Cytoband	q21.2
Chromosome location (bp)	59665583 - 60163987
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139734 (version 83.38)
Entrez gene	81624
UniProt	Q9NSV4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NSV4
Antibodypedia	DIAPH3 antibodies

PROTEIN BROWSER

DIAPH3-001	DIAPH3-002	DIAPH3-003	DIAPH3-005	DIAPH3-006	DIAPH3-007	DIAPH3-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DIAPH3-001 ENSP00000383178 ENST00000400324	Q9NSV4 [Direct mapping] Protein diaphanous homolog 3 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005488 [binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0007283 [spermatogenesis] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] Show all	1193 aa 136.9 kDa	No	0
DIAPH3-002 ENSP00000479091 ENST00000498416	Q9NSV4 [Direct mapping] Protein diaphanous homolog 3 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005488 [binding] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] Show all	691 aa 79.4 kDa	No	0
DIAPH3-003 ENSP00000267215 ENST00000267215	Q9NSV4 [Direct mapping] Protein diaphanous homolog 3 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005488 [binding] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] Show all	1112 aa 127.9 kDa	No	0
DIAPH3-005 ENSP00000367141 ENST00000377908	Q9NSV4 [Direct mapping] Protein diaphanous homolog 3 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005488 [binding] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] Show all	1182 aa 135.6 kDa	No	0
DIAPH3-006 ENSP00000383173 ENST00000400319	Q9NSV4 [Direct mapping] Protein diaphanous homolog 3 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005488 [binding] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] Show all	1123 aa 129 kDa	No	0
DIAPH3-007 ENSP00000383174 ENST00000400320	Q9NSV4 [Direct mapping] Protein diaphanous homolog 3 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005488 [binding] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] Show all	1147 aa 131.5 kDa	No	0
DIAPH3-008 ENSP00000478137 ENST00000465066	Q9NSV4 [Direct mapping] Protein diaphanous homolog 3 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005488 [binding] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] Show all	849 aa 98.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.