Cell atlas - ZIC5 - The Human Protein Atlas

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ZIC5

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	ZIC5
Gene description	Zic family member 5
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm & vesicles.
RNA cell category	Cell line enhanced (SCLC-21H, AF22)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (uncertain), Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA074045
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm & vesicles.

Main location

Nucleoplasm (uncertain), Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA074045	HEK 293	Nucleoplasm
	HPA074045	HEK 293	Vesicles
	HPA074045	U-2 OS	Nucleoplasm
	HPA074045	U-2 OS	Vesicles
	HPA074045	U-251 MG	Nucleoplasm
	HPA074045	U-251 MG	Vesicles

GENE INFORMATION
Gene name	ZIC5
Synonyms
Description	Zic family member 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 2, a related family member on chromosome 13. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q32.3
Chromosome location (bp)	99962964 - 99971909
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139800 (version 83.38)
Entrez gene	85416
UniProt	Q96T25 (UniProt - Evidence at protein level)
neXtProt	NX_Q96T25
Antibodypedia	ZIC5 antibodies

PROTEIN BROWSER

ZIC5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZIC5-001 ENSP00000267294 ENST00000267294	Q96T25 [Direct mapping] Zinc finger protein ZIC 5 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0007399 [nervous system development] GO:0030154 [cell differentiation] GO:0046872 [metal ion binding] Show all	663 aa 68.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.