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CUL4A

GENERAL INFORMATION

Gene name

 CUL4A

Gene description

 Cullin 4A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CUL4A

Synonyms

Description

 Cullin 4A (HGNC Symbol)

Entrez gene summary

 CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]

Chromosome

 13

Cytoband

 q34

Chromosome location (bp)

 113208193 - 113267108

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139842 (version 83.38)

Entrez gene

 8451

UniProt

 Q13619 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13619

Antibodypedia

 CUL4A antibodies

PROTEIN BROWSER
CUL4A-001
CUL4A-002
CUL4A-007
CUL4A-201
CUL4A-202
CUL4A-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CUL4A-001
ENSP00000481782
ENST00000617546
Q13619 [Direct mapping]
Cullin-4A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007050 [cell cycle arrest]
GO:0008285 [negative regulation of cell proliferation]
GO:0016032 [viral process]
GO:0019985 [translesion synthesis]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031464 [Cul4A-RING E3 ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070911 [global genome nucleotide-excision repair]
GO:0080008 [Cul4-RING E3 ubiquitin ligase complex]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 659 aa
76.8 kDa 		No 0
CUL4A-002
ENSP00000364589
ENST00000375440
Q13619 [Direct mapping]
Cullin-4A
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0001701 [in utero embryonic development]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007050 [cell cycle arrest]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0016032 [viral process]
GO:0019985 [translesion synthesis]
GO:0030097 [hemopoiesis]
GO:0030853 [negative regulation of granulocyte differentiation]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031464 [Cul4A-RING E3 ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0035019 [somatic stem cell population maintenance]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051246 [regulation of protein metabolic process]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070911 [global genome nucleotide-excision repair]
GO:0080008 [Cul4-RING E3 ubiquitin ligase complex]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:2000001 [regulation of DNA damage checkpoint]
GO:2000819 [regulation of nucleotide-excision repair]
Show all
 759 aa
87.7 kDa 		No 0
CUL4A-007
ENSP00000480367
ENST00000488558
A0A087WWN2 [Direct mapping]
Cullin-4A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
Show all
 174 aa
19.7 kDa 		No 0
CUL4A-201
ENSP00000322132
ENST00000326335
A0A0A0MR50 [Direct mapping]
Cullin-4A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
Show all
 667 aa
77.7 kDa 		No 0
CUL4A-202
ENSP00000364590
ENST00000375441
Q13619 [Direct mapping]
Cullin-4A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007050 [cell cycle arrest]
GO:0008285 [negative regulation of cell proliferation]
GO:0016032 [viral process]
GO:0019985 [translesion synthesis]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031464 [Cul4A-RING E3 ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070911 [global genome nucleotide-excision repair]
GO:0080008 [Cul4-RING E3 ubiquitin ligase complex]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 659 aa
76.8 kDa 		No 0
CUL4A-203
ENSP00000389118
ENST00000451881
Q13619 [Direct mapping]
Cullin-4A
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007050 [cell cycle arrest]
GO:0008285 [negative regulation of cell proliferation]
GO:0016032 [viral process]
GO:0019985 [translesion synthesis]
GO:0031461 [cullin-RING ubiquitin ligase complex]
GO:0031464 [Cul4A-RING E3 ubiquitin ligase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070911 [global genome nucleotide-excision repair]
GO:0080008 [Cul4-RING E3 ubiquitin ligase complex]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 659 aa
76.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.