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SLC12A6

GENERAL INFORMATION

Gene name

 SLC12A6

Gene description

 Solute carrier family 12 (potassium/chloride transporter), member 6

Protein class

 Disease related genes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 13
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Caution, Splice and/or transcript discrepancy exists. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA034563
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SLC12A6 (HGNC Symbol)

Synonyms

 ACCPN, KCC3

Description

 Solute carrier family 12 (potassium/chloride transporter), member 6 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q14

Chromosome location (bp)

 34229996 - 34338060

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140199 (version 83.38)

Entrez gene

 9990

UniProt

 Q9UHW9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHW9

Antibodypedia

 SLC12A6 antibodies

PROTEIN BROWSER
«
SLC12A6-001
SLC12A6-002
SLC12A6-003
SLC12A6-004
SLC12A6-006
SLC12A6-008
SLC12A6-009
SLC12A6-010
SLC12A6-011
SLC12A6-012
SLC12A6-013
SLC12A6-017
SLC12A6-018
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC12A6-001
ENSP00000290209
ENST00000290209
Q9UHW9 [Direct mapping]
Solute carrier family 12 member 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005215 [transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006884 [cell volume homeostasis]
GO:0010107 [potassium ion import]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015377 [cation:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0019901 [protein kinase binding]
GO:0022820 [potassium ion symporter activity]
GO:0035826 [rubidium ion transport]
GO:0035827 [rubidium ion transmembrane transporter activity]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0071476 [cellular hypotonic response]
GO:0071477 [cellular hypotonic salinity response]
GO:0071805 [potassium ion transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1099 aa
122.1 kDa 		No >9
SLC12A6-002
ENSP00000380819
ENST00000397707
Q9UHW9 [Direct mapping]
Solute carrier family 12 member 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005215 [transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006884 [cell volume homeostasis]
GO:0010107 [potassium ion import]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015377 [cation:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0019901 [protein kinase binding]
GO:0022820 [potassium ion symporter activity]
GO:0035826 [rubidium ion transport]
GO:0035827 [rubidium ion transmembrane transporter activity]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0071476 [cellular hypotonic response]
GO:0071477 [cellular hypotonic salinity response]
GO:0071805 [potassium ion transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1135 aa
126 kDa 		No >9
SLC12A6-003
ENSP00000346112
ENST00000354181
Q9UHW9 [Direct mapping]
Solute carrier family 12 member 6
A0A024R9I5 [Target identity:100%; Query identity:100%]
Solute carrier family 12 (Potassium/chloride transporters), member 6, isoform CRA_d
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005215 [transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006884 [cell volume homeostasis]
GO:0010107 [potassium ion import]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015377 [cation:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0019901 [protein kinase binding]
GO:0022820 [potassium ion symporter activity]
GO:0035826 [rubidium ion transport]
GO:0035827 [rubidium ion transmembrane transporter activity]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0071476 [cellular hypotonic response]
GO:0071477 [cellular hypotonic salinity response]
GO:0071805 [potassium ion transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1150 aa
127.6 kDa 		No >9
SLC12A6-004
ENSP00000452776
ENST00000558589
Q9UHW9 [Direct mapping]
Solute carrier family 12 member 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005215 [transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006884 [cell volume homeostasis]
GO:0010107 [potassium ion import]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015377 [cation:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0019901 [protein kinase binding]
GO:0022820 [potassium ion symporter activity]
GO:0035826 [rubidium ion transport]
GO:0035827 [rubidium ion transmembrane transporter activity]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0071476 [cellular hypotonic response]
GO:0071477 [cellular hypotonic salinity response]
GO:0071805 [potassium ion transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1141 aa
126.6 kDa 		No >9
SLC12A6-006
ENSP00000387725
ENST00000458406
Q9UHW9 [Direct mapping]
Solute carrier family 12 member 6
A0A024R9K8 [Target identity:100%; Query identity:100%]
Solute carrier family 12 (Potassium/chloride transporters), member 6, isoform CRA_a
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005215 [transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006884 [cell volume homeostasis]
GO:0010107 [potassium ion import]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015377 [cation:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0019901 [protein kinase binding]
GO:0022820 [potassium ion symporter activity]
GO:0035826 [rubidium ion transport]
GO:0035827 [rubidium ion transmembrane transporter activity]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0071476 [cellular hypotonic response]
GO:0071477 [cellular hypotonic salinity response]
GO:0071805 [potassium ion transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1091 aa
121.1 kDa 		No >9
SLC12A6-008
ENSP00000380814
ENST00000397702
Q9UHW9 [Direct mapping]
Solute carrier family 12 member 6
A0A024R9K8 [Target identity:100%; Query identity:100%]
Solute carrier family 12 (Potassium/chloride transporters), member 6, isoform CRA_a
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005215 [transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006884 [cell volume homeostasis]
GO:0010107 [potassium ion import]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015377 [cation:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0019901 [protein kinase binding]
GO:0022820 [potassium ion symporter activity]
GO:0035826 [rubidium ion transport]
GO:0035827 [rubidium ion transmembrane transporter activity]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0071476 [cellular hypotonic response]
GO:0071477 [cellular hypotonic salinity response]
GO:0071805 [potassium ion transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1091 aa
121.1 kDa 		No >9
SLC12A6-009
ENSP00000453473
ENST00000558667
Q9UHW9 [Direct mapping]
Solute carrier family 12 member 6
A0A024R9I5 [Target identity:100%; Query identity:100%]
Solute carrier family 12 (Potassium/chloride transporters), member 6, isoform CRA_d
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005215 [transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006884 [cell volume homeostasis]
GO:0010107 [potassium ion import]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015377 [cation:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0019901 [protein kinase binding]
GO:0022820 [potassium ion symporter activity]
GO:0035826 [rubidium ion transport]
GO:0035827 [rubidium ion transmembrane transporter activity]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0071476 [cellular hypotonic response]
GO:0071477 [cellular hypotonic salinity response]
GO:0071805 [potassium ion transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1150 aa
127.6 kDa 		No >9
SLC12A6-010
ENSP00000454168
ENST00000560611
Q9UHW9 [Direct mapping]
Solute carrier family 12 member 6
A0A024R9I5 [Target identity:100%; Query identity:100%]
Solute carrier family 12 (Potassium/chloride transporters), member 6, isoform CRA_d
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005215 [transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006884 [cell volume homeostasis]
GO:0010107 [potassium ion import]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015377 [cation:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0019901 [protein kinase binding]
GO:0022820 [potassium ion symporter activity]
GO:0035826 [rubidium ion transport]
GO:0035827 [rubidium ion transmembrane transporter activity]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0071476 [cellular hypotonic response]
GO:0071477 [cellular hypotonic salinity response]
GO:0071805 [potassium ion transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1150 aa
127.6 kDa 		No >9
SLC12A6-011
ENSP00000452828
ENST00000559236
H0YKJ2 [Direct mapping]
Solute carrier family 12 member 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 135 aa
14.8 kDa 		No 0
SLC12A6-012
ENSP00000452771
ENST00000561120
H0YKE6 [Direct mapping]
Solute carrier family 12 member 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 152 aa
16.9 kDa 		No 0
SLC12A6-013
ENSP00000452857
ENST00000559484
H0YKL8 [Direct mapping]
Solute carrier family 12 member 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 61 aa
6.6 kDa 		No 0
SLC12A6-017
ENSP00000452705
ENST00000560164
B3KXX3 [Direct mapping]
Solute carrier family 12 member 6; cDNA FLJ46254 fis, clone TESTI4023096, highly similar to Solute carrier family 12 member 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0015377 [cation:chloride symporter activity]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 962 aa
106.9 kDa 		No >9
SLC12A6-018
ENSP00000454037
ENST00000560332
H0YNJ5 [Direct mapping]
Solute carrier family 12 member 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
Show all
 107 aa
11.6 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.