Expression of SORD in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Sorbitol dehydrogenase

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Endometrial cancer

STAINING SUMMARY

HPA040260	HPA040621

GENE INFORMATION
Gene name	SORD
Synonyms
Description	Sorbitol dehydrogenase (HGNC Symbol)
Entrez gene summary	Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]
Chromosome	15
Cytoband	q21.1
Chromosome location (bp)	45023104 - 45077185
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140263 (version 83.38)
Entrez gene	6652
UniProt	Q00796 (UniProt - Evidence at protein level)
neXtProt	NX_Q00796
Antibodypedia	SORD antibodies

PROTEIN BROWSER

SORD-001	SORD-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SORD-001 ENSP00000267814 ENST00000267814	Q00796 [Direct mapping] Sorbitol dehydrogenase Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003939 [L-iditol 2-dehydrogenase activity] GO:0005615 [extracellular space] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006000 [fructose metabolic process] GO:0006006 [glucose metabolic process] GO:0006060 [sorbitol metabolic process] GO:0006062 [sorbitol catabolic process] GO:0006970 [response to osmotic stress] GO:0008270 [zinc ion binding] GO:0009725 [response to hormone] GO:0016020 [membrane] GO:0016491 [oxidoreductase activity] GO:0019640 [glucuronate catabolic process to xylulose 5-phosphate] GO:0030246 [carbohydrate binding] GO:0030317 [sperm motility] GO:0031514 [motile cilium] GO:0031667 [response to nutrient levels] GO:0031966 [mitochondrial membrane] GO:0042493 [response to drug] GO:0042802 [identical protein binding] GO:0044281 [small molecule metabolic process] GO:0046370 [fructose biosynthetic process] GO:0046526 [D-xylulose reductase activity] GO:0046686 [response to cadmium ion] GO:0046688 [response to copper ion] GO:0051160 [L-xylitol catabolic process] GO:0051164 [L-xylitol metabolic process] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	357 aa 38.3 kDa	No	0
SORD-004 ENSP00000453122 ENST00000558580	H0YLA4 [Direct mapping] Sorbitol dehydrogenase Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	336 aa 36.2 kDa	No	0