Tissue expression of DUOX2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DUOX2
Gene description	Dual oxidase 2
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (gallbladder, thyroid gland, urinary bladder)
GTEx:	Tissue enhanced (thyroid gland)
FANTOM5:	Tissue enhanced (gallbladder, thyroid gland)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (gallbladder, thyroid gland, urinary bladder)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (thyroid gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (gallbladder, thyroid gland)

GENE INFORMATION
Gene name	DUOX2 (HGNC Symbol)
Synonyms	LNOX2, P138(TOX), P138-TOX, THOX2
Description	Dual oxidase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q21.1
Chromosome location (bp)	45092650 - 45114344
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140279 (version 83.38)
Entrez gene	50506
UniProt	Q9NRD8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRD8
Antibodypedia	DUOX2 antibodies

PROTEIN BROWSER

DUOX2-001	DUOX2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DUOX2-001 ENSP00000373691 ENST00000389039	X6RAN8 [Direct mapping] Dual oxidase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0004601 [peroxidase activity] GO:0005509 [calcium ion binding] GO:0006979 [response to oxidative stress] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	1548 aa 175.3 kDa	Yes	9
DUOX2-201 ENSP00000475084 ENST00000603300	Q9NRD8 [Direct mapping] Dual oxidase 2 Show all	Enzymes ENZYME proteins Oxidoreductases Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004601 [peroxidase activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0006590 [thyroid hormone generation] GO:0006979 [response to oxidative stress] GO:0009566 [fertilization] GO:0009615 [response to virus] GO:0016021 [integral component of membrane] GO:0016174 [NAD(P)H oxidase activity] GO:0016324 [apical plasma membrane] GO:0016491 [oxidoreductase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0020037 [heme binding] GO:0030282 [bone mineralization] GO:0030878 [thyroid gland development] GO:0034641 [cellular nitrogen compound metabolic process] GO:0035264 [multicellular organism growth] GO:0042335 [cuticle development] GO:0042403 [thyroid hormone metabolic process] GO:0042445 [hormone metabolic process] GO:0042446 [hormone biosynthetic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0044281 [small molecule metabolic process] GO:0048839 [inner ear development] GO:0048855 [adenohypophysis morphogenesis] GO:0051591 [response to cAMP] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	1548 aa 175.4 kDa	Yes	9