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SLC27A2

GENERAL INFORMATION

Gene name

 SLC27A2

Gene description

 Solute carrier family 27 (fatty acid transporter), member 2

Protein class

 Enzymes
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (kidney, liver, epididymis)
GTEx:Tissue enhanced (liver)
FANTOM5:Tissue enhanced (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in renal tubules of kidney and hepatocytes in liver.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA026089
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (kidney, liver, epididymis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver)

GENE INFORMATION

Gene name

 SLC27A2 (HGNC Symbol)

Synonyms

 ACSVL1, FACVL1, FATP2, hFACVL1, HsT17226, VLACS, VLCS

Description

 Solute carrier family 27 (fatty acid transporter), member 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Chromosome

 15

Cytoband

 q21.2

Chromosome location (bp)

 50182196 - 50236395

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140284 (version 83.38)

Entrez gene

 11001

UniProt

 O14975 (UniProt - Evidence at protein level)

neXtProt

 NX_O14975

Antibodypedia

 SLC27A2 antibodies

PROTEIN BROWSER
SLC27A2-001
SLC27A2-002
SLC27A2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC27A2-001
ENSP00000267842
ENST00000267842
O14975 [Direct mapping]
Very long-chain acyl-CoA synthetase
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Enzymes
   ENZYME proteins
   Ligase
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000038 [very long-chain fatty acid metabolic process]
GO:0001561 [fatty acid alpha-oxidation]
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005102 [receptor binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005778 [peroxisomal membrane]
GO:0005779 [integral component of peroxisomal membrane]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006635 [fatty acid beta-oxidation]
GO:0006699 [bile acid biosynthetic process]
GO:0008152 [metabolic process]
GO:0008206 [bile acid metabolic process]
GO:0015245 [fatty acid transporter activity]
GO:0015908 [fatty acid transport]
GO:0019899 [enzyme binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031957 [very long-chain fatty acid-CoA ligase activity]
GO:0042760 [very long-chain fatty acid catabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044539 [long-chain fatty acid import]
GO:0050197 [phytanate-CoA ligase activity]
GO:0070062 [extracellular exosome]
GO:0070251 [pristanate-CoA ligase activity]
GO:0097089 [methyl-branched fatty acid metabolic process]
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 620 aa
70.3 kDa 		Yes 2
SLC27A2-002
ENSP00000370289
ENST00000380902
O14975 [Direct mapping]
Very long-chain acyl-CoA synthetase
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Enzymes
   ENZYME proteins
   Ligase
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001561 [fatty acid alpha-oxidation]
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005102 [receptor binding]
GO:0005524 [ATP binding]
GO:0005778 [peroxisomal membrane]
GO:0005779 [integral component of peroxisomal membrane]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006635 [fatty acid beta-oxidation]
GO:0006699 [bile acid biosynthetic process]
GO:0008152 [metabolic process]
GO:0008206 [bile acid metabolic process]
GO:0019899 [enzyme binding]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0031957 [very long-chain fatty acid-CoA ligase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044539 [long-chain fatty acid import]
GO:0050197 [phytanate-CoA ligase activity]
GO:0070062 [extracellular exosome]
GO:0070251 [pristanate-CoA ligase activity]
GO:0097089 [methyl-branched fatty acid metabolic process]
Show all
 567 aa
64.6 kDa 		Yes 1
SLC27A2-003
ENSP00000444549
ENST00000544960
G3V1R7 [Direct mapping]
Solute carrier family 27 (Fatty acid transporter), member 2, isoform CRA_b; Very long-chain acyl-CoA synthetase
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0008152 [metabolic process]
GO:0015908 [fatty acid transport]
GO:0016021 [integral component of membrane]
GO:0031957 [very long-chain fatty acid-CoA ligase activity]
Show all
 385 aa
44 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.