Expression of GCNT3 in cancer - Summary

CANCER ATLAS

Gene description

Glucosaminyl (N-acetyl) transferase 3, mucin type

Protein class

Enzymes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA011154

GENE INFORMATION
Gene name	GCNT3 (HGNC Symbol)
Synonyms	C2/4GnT, C2GnT-M, C2GnT2
Description	Glucosaminyl (N-acetyl) transferase 3, mucin type (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009]
Chromosome	15
Cytoband	q22.2
Chromosome location (bp)	59594875 - 59640239
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140297 (version 83.38)
Entrez gene	9245
UniProt	O95395 (UniProt - Evidence at transcript level)
neXtProt	NX_O95395
Antibodypedia	GCNT3 antibodies

PROTEIN BROWSER

GCNT3-001	GCNT3-005	GCNT3-007	GCNT3-008	GCNT3-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GCNT3-001 ENSP00000379377 ENST00000396065	O95395 [Direct mapping] Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 A0A024R5T9 [Target identity:100%; Query identity:100%] Glucosaminyl (N-acetyl) transferase 3, mucin type, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002426 [immunoglobulin production in mucosal tissue] GO:0003829 [beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006493 [protein O-linked glycosylation] GO:0008109 [N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0047225 [acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity] GO:0048729 [tissue morphogenesis] GO:0050892 [intestinal absorption] GO:0060993 [kidney morphogenesis] GO:0070062 [extracellular exosome] Show all	438 aa 50.9 kDa	No	1
GCNT3-005 ENSP00000453453 ENST00000559189	H0YM40 [Direct mapping] Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	87 aa 10 kDa	No	1
GCNT3-007 ENSP00000453928 ENST00000559626	H0YNA3 [Direct mapping] Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	53 aa 6.3 kDa	No	1
GCNT3-008 ENSP00000452741 ENST00000560585	O95395 [Direct mapping] Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 A0A024R5T9 [Target identity:100%; Query identity:100%] Glucosaminyl (N-acetyl) transferase 3, mucin type, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003829 [beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006493 [protein O-linked glycosylation] GO:0008109 [N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	438 aa 50.9 kDa	No	1
GCNT3-010 ENSP00000453774 ENST00000559200	H0YMW7 [Direct mapping] Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	153 aa 18 kDa	No	1