Cell atlas - SRP14 - The Human Protein Atlas

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SRP14

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SRP14
Gene description	Signal recognition particle 14kDa (homologous Alu RNA binding protein)
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins Transporters
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)
Additional location	In addition localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA053738 , HPA065118
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the nucleus.

Main location

Nucleoli (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053738	MCF7	Nucleus
	HPA053738	MCF7	Nucleoli
	HPA053738	PC-3	Nucleus
			Nucleoli
			Cytosol
	HPA053738	U-2 OS	No staining
	HPA065118	PC-3	Nucleus
	HPA065118	PC-3	Nucleoli
	HPA065118	SH-SY5Y	Nucleus
	HPA065118	SH-SY5Y	Nucleoli
	HPA065118	U-2 OS	Nucleus
	HPA065118	U-2 OS	Nucleoli

GENE INFORMATION
Gene name	SRP14 (HGNC Symbol)
Synonyms	ALURBP, MGC14326
Description	Signal recognition particle 14kDa (homologous Alu RNA binding protein) (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	40035739 - 40039188
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140319 (version 83.38)
Entrez gene	6727
UniProt	P37108 (UniProt - Evidence at protein level)
neXtProt	NX_P37108
Antibodypedia	SRP14 antibodies

PROTEIN BROWSER

SRP14-001	SRP14-004	SRP14-005	SRP14-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SRP14-001 ENSP00000267884 ENST00000267884	P37108 [Direct mapping] Signal recognition particle 14 kDa protein Show all	Transporters Primary Active Transporters Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005786 [signal recognition particle, endoplasmic reticulum targeting] GO:0005829 [cytosol] GO:0006412 [translation] GO:0006613 [cotranslational protein targeting to membrane] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0008312 [7S RNA binding] GO:0010467 [gene expression] GO:0030942 [endoplasmic reticulum signal peptide binding] GO:0042493 [response to drug] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0045047 [protein targeting to ER] GO:0045171 [intercellular bridge] GO:0048500 [signal recognition particle] GO:0070062 [extracellular exosome] Show all	136 aa 14.6 kDa	No	0
SRP14-004 ENSP00000452756 ENST00000560773	H0YLW0 [Direct mapping] Signal recognition particle 14 kDa protein Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0008312 [7S RNA binding] GO:0048500 [signal recognition particle] Show all	56 aa 5.5 kDa	Yes	0
SRP14-005 ENSP00000453361 ENST00000558720	H0YLW0 [Direct mapping] Signal recognition particle 14 kDa protein Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0008312 [7S RNA binding] GO:0048500 [signal recognition particle] Show all	56 aa 5.5 kDa	Yes	0
SRP14-007 ENSP00000453120 ENST00000559081	H0YLA2 [Direct mapping] Signal recognition particle 14 kDa protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005786 [signal recognition particle, endoplasmic reticulum targeting] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0008312 [7S RNA binding] GO:0030942 [endoplasmic reticulum signal peptide binding] GO:0048500 [signal recognition particle] Show all	115 aa 13.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.