Tissue expression of BCL2A1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	BCL2A1
Gene description	BCL2-related protein A1
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (bone marrow, appendix)
GTEx:	Group enriched (spleen, lung)
FANTOM5:	Tissue enhanced (lung)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (bone marrow, appendix)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (spleen, lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)

GENE INFORMATION
Gene name	BCL2A1 (HGNC Symbol)
Synonyms	ACC-1, ACC-2, ACC1, ACC2, BCL2L5, BFL1, GRS, HBPA1
Description	BCL2-related protein A1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q25.1
Chromosome location (bp)	79960889 - 79971446
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140379 (version 83.38)
Entrez gene	597
UniProt	Q16548 (UniProt - Evidence at protein level)
neXtProt	NX_Q16548
Antibodypedia	BCL2A1 antibodies

PROTEIN BROWSER

BCL2A1-001	BCL2A1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCL2A1-001 ENSP00000267953 ENST00000267953	Q16548 [Direct mapping] Bcl-2-related protein A1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005741 [mitochondrial outer membrane] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] Show all	175 aa 20.1 kDa	No	0
BCL2A1-002 ENSP00000335250 ENST00000335661	Q16548 [Direct mapping] Bcl-2-related protein A1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005741 [mitochondrial outer membrane] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] Show all	163 aa 18.7 kDa	No	0