Cell atlas - NEIL1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

NEIL1

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	NEIL1
Gene description	Nei-like DNA glycosylase 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	13
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA054084
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA054084	HEK 293	Nucleoplasm
	HPA054084	HeLa	Nucleoplasm
	HPA054084	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	NEIL1 (HGNC Symbol)
Synonyms	FLJ22402, FPG1, hFPG1, NEI1
Description	Nei-like DNA glycosylase 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Chromosome	15
Cytoband	q24.2
Chromosome location (bp)	75346955 - 75357114
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140398 (version 83.38)
Entrez gene	79661
UniProt	Q96FI4 (UniProt - Evidence at protein level)
neXtProt	NX_Q96FI4
Antibodypedia	NEIL1 antibodies

PROTEIN BROWSER

NEIL1-001	NEIL1-003	NEIL1-004	NEIL1-006	NEIL1-007	NEIL1-008	NEIL1-009	NEIL1-010	NEIL1-014	NEIL1-016	NEIL1-017	NEIL1-018	NEIL1-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NEIL1-001 ENSP00000347170 ENST00000355059	Q96FI4 [Direct mapping] Endonuclease 8-like 1 Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003684 [damaged DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006285 [base-excision repair, AP site formation] GO:0006289 [nucleotide-excision repair] GO:0006979 [response to oxidative stress] GO:0008022 [protein C-terminus binding] GO:0008270 [zinc ion binding] GO:0016798 [hydrolase activity, acting on glycosyl bonds] GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds] GO:0016829 [lyase activity] GO:0019104 [DNA N-glycosylase activity] GO:0032074 [negative regulation of nuclease activity] GO:0045008 [depyrimidination] Show all	390 aa 43.7 kDa	No	0
NEIL1-003 ENSP00000457352 ENST00000564784	Q96FI4 [Direct mapping] Endonuclease 8-like 1 Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Show all	GO:0003676 [nucleic acid binding] GO:0003684 [damaged DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006285 [base-excision repair, AP site formation] GO:0006289 [nucleotide-excision repair] GO:0006979 [response to oxidative stress] GO:0008022 [protein C-terminus binding] GO:0008270 [zinc ion binding] GO:0016798 [hydrolase activity, acting on glycosyl bonds] GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds] GO:0032074 [negative regulation of nuclease activity] GO:0045008 [depyrimidination] Show all	390 aa 43.7 kDa	No	0
NEIL1-004 ENSP00000455730 ENST00000569035	Q96FI4 [Direct mapping] Endonuclease 8-like 1 Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003684 [damaged DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006285 [base-excision repair, AP site formation] GO:0006289 [nucleotide-excision repair] GO:0006979 [response to oxidative stress] GO:0008022 [protein C-terminus binding] GO:0008270 [zinc ion binding] GO:0016798 [hydrolase activity, acting on glycosyl bonds] GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds] GO:0032074 [negative regulation of nuclease activity] GO:0045008 [depyrimidination] Show all	390 aa 43.7 kDa	No	0
NEIL1-006 ENSP00000456466 ENST00000564500	H3BRZ2 [Direct mapping] Endonuclease 8-like 1 Show all	Predicted intracellular proteins Show all		22 aa 2.4 kDa	No	0
NEIL1-007 ENSP00000457541 ENST00000566752	H3BU98 [Direct mapping] Endonuclease 8-like 1 Show all	Predicted intracellular proteins Show all	GO:0003684 [damaged DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0006284 [base-excision repair] GO:0008270 [zinc ion binding] GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds] Show all	64 aa 6.9 kDa	No	0
NEIL1-008 ENSP00000457081 ENST00000566313	H3BT94 [Direct mapping] Endonuclease 8-like 1 Show all	Predicted intracellular proteins Show all		51 aa 5.5 kDa	No	0
NEIL1-009 ENSP00000455745 ENST00000568059	H3BQE8 [Direct mapping] Endonuclease 8-like 1 Show all	Predicted intracellular proteins Show all	GO:0003684 [damaged DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0006284 [base-excision repair] GO:0008270 [zinc ion binding] GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds] Show all	88 aa 9.5 kDa	No	0
NEIL1-010 ENSP00000454729 ENST00000568881	H3BN83 [Direct mapping] Endonuclease 8-like 1 Show all	Predicted intracellular proteins Show all		39 aa 4.2 kDa	No	0
NEIL1-014 ENSP00000455949 ENST00000567657	H3BQU8 [Direct mapping] Endonuclease 8-like 1 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0003684 [damaged DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0006284 [base-excision repair] GO:0006289 [nucleotide-excision repair] GO:0008270 [zinc ion binding] GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds] Show all	185 aa 21 kDa	No	0
NEIL1-016 ENSP00000457056 ENST00000565051	H3BT75 [Direct mapping] Endonuclease 8-like 1 Show all	Predicted intracellular proteins Show all	GO:0003684 [damaged DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0006284 [base-excision repair] GO:0008270 [zinc ion binding] GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds] Show all	199 aa 22.5 kDa	No	0
NEIL1-017 ENSP00000456852 ENST00000564257	H3BST2 [Direct mapping] Endonuclease 8-like 1 Show all	Predicted intracellular proteins Show all	GO:0003684 [damaged DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0006284 [base-excision repair] GO:0008270 [zinc ion binding] GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds] Show all	132 aa 14.7 kDa	No	0
NEIL1-018 ENSP00000454292 ENST00000567005	H3BM98 [Direct mapping] Endonuclease 8-like 1 Show all	Predicted intracellular proteins Show all	GO:0003684 [damaged DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0006284 [base-excision repair] GO:0008270 [zinc ion binding] GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds] Show all	155 aa 17.4 kDa	No	0
NEIL1-019 ENSP00000457371 ENST00000569506	H3BTX5 [Direct mapping] Endonuclease 8-like 1 Show all	Predicted intracellular proteins Show all	GO:0003684 [damaged DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0006284 [base-excision repair] GO:0008270 [zinc ion binding] GO:0016799 [hydrolase activity, hydrolyzing N-glycosyl compounds] Show all	82 aa 8.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.