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TPM1

GENERAL INFORMATION

Gene name

 TPM1

Gene description

 Tropomyosin 1 (alpha)

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 19
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression, mainly in skeletal, heart and smooth muscle cells.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Supported based on 5 antibodies.
HPA000261 , HPA009066 , HPA047089 , HPA053624 , CAB017698
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin01,0002,0003,0004,0005,0006,0007,000TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin02004006008001,000RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina02,0004,0006,0008,000Tags Per Million

GENE INFORMATION

Gene name

 TPM1 (HGNC Symbol)

Synonyms

 C15orf13, CMH3

Description

 Tropomyosin 1 (alpha) (HGNC Symbol)

Entrez gene summary

 This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q22.2

Chromosome location (bp)

 63042632 - 63071915

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140416 (version 83.38)

Entrez gene

 7168

UniProt

 P09493 (UniProt - Evidence at protein level)

neXtProt

 NX_P09493

Antibodypedia

 TPM1 antibodies

PROTEIN BROWSER
«
TPM1-001
TPM1-002
TPM1-003
TPM1-005
TPM1-008
TPM1-010
TPM1-011
TPM1-012
TPM1-014
TPM1-015
TPM1-016
TPM1-018
TPM1-019
TPM1-022
TPM1-023
TPM1-024
TPM1-027
TPM1-028
TPM1-034
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TPM1-001
ENSP00000288398
ENST00000288398
P09493 [Direct mapping]
Tropomyosin alpha-1 chain
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003065 [positive regulation of heart rate by epinephrine]
GO:0003779 [actin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005862 [muscle thin filament tropomyosin]
GO:0006928 [movement of cell or subcellular component]
GO:0006936 [muscle contraction]
GO:0006937 [regulation of muscle contraction]
GO:0007010 [cytoskeleton organization]
GO:0008016 [regulation of heart contraction]
GO:0008092 [cytoskeletal protein binding]
GO:0008307 [structural constituent of muscle]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030336 [negative regulation of cell migration]
GO:0031529 [ruffle organization]
GO:0032059 [bleb]
GO:0032587 [ruffle membrane]
GO:0032781 [positive regulation of ATPase activity]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042060 [wound healing]
GO:0045214 [sarcomere organization]
GO:0045785 [positive regulation of cell adhesion]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
Show all
 284 aa
32.9 kDa 		No 0
TPM1-002
ENSP00000385107
ENST00000403994
P09493 [Direct mapping]
Tropomyosin alpha-1 chain
D9YZV4 [Target identity:100%; Query identity:100%]
Tropomyosin 1 (Alpha) isoform 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003065 [positive regulation of heart rate by epinephrine]
GO:0003779 [actin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005862 [muscle thin filament tropomyosin]
GO:0006928 [movement of cell or subcellular component]
GO:0006936 [muscle contraction]
GO:0006937 [regulation of muscle contraction]
GO:0007010 [cytoskeleton organization]
GO:0008016 [regulation of heart contraction]
GO:0008092 [cytoskeletal protein binding]
GO:0008307 [structural constituent of muscle]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030336 [negative regulation of cell migration]
GO:0031529 [ruffle organization]
GO:0032059 [bleb]
GO:0032587 [ruffle membrane]
GO:0032781 [positive regulation of ATPase activity]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042060 [wound healing]
GO:0045214 [sarcomere organization]
GO:0045785 [positive regulation of cell adhesion]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
Show all
 284 aa
32.7 kDa 		No 0
TPM1-003
ENSP00000453062
ENST00000560970
H0YL52 [Direct mapping]
Tropomyosin alpha-1 chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 265 aa
30.4 kDa 		No 0
TPM1-005
ENSP00000267996
ENST00000267996
P09493 [Direct mapping]
Tropomyosin alpha-1 chain
A0A024R5W6 [Target identity:100%; Query identity:100%]
Tropomyosin 1 (Alpha), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003065 [positive regulation of heart rate by epinephrine]
GO:0003779 [actin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005862 [muscle thin filament tropomyosin]
GO:0006928 [movement of cell or subcellular component]
GO:0006936 [muscle contraction]
GO:0006937 [regulation of muscle contraction]
GO:0007010 [cytoskeleton organization]
GO:0008016 [regulation of heart contraction]
GO:0008092 [cytoskeletal protein binding]
GO:0008307 [structural constituent of muscle]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030336 [negative regulation of cell migration]
GO:0031529 [ruffle organization]
GO:0032059 [bleb]
GO:0032587 [ruffle membrane]
GO:0032781 [positive regulation of ATPase activity]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042060 [wound healing]
GO:0045214 [sarcomere organization]
GO:0045785 [positive regulation of cell adhesion]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
Show all
 284 aa
32.7 kDa 		No 0
TPM1-008
ENSP00000350667
ENST00000357980
Q6ZN40 [Direct mapping]
Tropomyosin 1 (Alpha), isoform CRA_f; Tropomyosin alpha-1 chain; cDNA FLJ16459 fis, clone BRCAN2002473, moderately similar to Tropomyosin, fibroblast isoform 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 326 aa
37.5 kDa 		No 0
TPM1-010
ENSP00000452879
ENST00000559397
P09493 [Direct mapping]
Tropomyosin alpha-1 chain
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003065 [positive regulation of heart rate by epinephrine]
GO:0003779 [actin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005862 [muscle thin filament tropomyosin]
GO:0006928 [movement of cell or subcellular component]
GO:0006936 [muscle contraction]
GO:0006937 [regulation of muscle contraction]
GO:0007010 [cytoskeleton organization]
GO:0008016 [regulation of heart contraction]
GO:0008092 [cytoskeletal protein binding]
GO:0008307 [structural constituent of muscle]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030336 [negative regulation of cell migration]
GO:0031529 [ruffle organization]
GO:0032059 [bleb]
GO:0032587 [ruffle membrane]
GO:0032781 [positive regulation of ATPase activity]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042060 [wound healing]
GO:0045214 [sarcomere organization]
GO:0045785 [positive regulation of cell adhesion]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
Show all
 284 aa
32.8 kDa 		No 0
TPM1-011
ENSP00000334624
ENST00000334895
P09493 [Direct mapping]
Tropomyosin alpha-1 chain
D9YZV7 [Target identity:100%; Query identity:100%]
Tropomyosin 1 (Alpha) isoform 6
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003065 [positive regulation of heart rate by epinephrine]
GO:0003779 [actin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005862 [muscle thin filament tropomyosin]
GO:0006928 [movement of cell or subcellular component]
GO:0006936 [muscle contraction]
GO:0006937 [regulation of muscle contraction]
GO:0007010 [cytoskeleton organization]
GO:0008016 [regulation of heart contraction]
GO:0008092 [cytoskeletal protein binding]
GO:0008307 [structural constituent of muscle]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030336 [negative regulation of cell migration]
GO:0031529 [ruffle organization]
GO:0032059 [bleb]
GO:0032587 [ruffle membrane]
GO:0032781 [positive regulation of ATPase activity]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042060 [wound healing]
GO:0045214 [sarcomere organization]
GO:0045785 [positive regulation of cell adhesion]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
Show all
 245 aa
28.4 kDa 		No 0
TPM1-012
ENSP00000384315
ENST00000404484
H7BYY1 [Direct mapping]
Tropomyosin 1 (Alpha), isoform CRA_m; Tropomyosin alpha-1 chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 248 aa
28.7 kDa 		No 0
TPM1-014
ENSP00000453724
ENST00000560959
B7Z596 [Direct mapping]
Tropomyosin alpha-1 chain; cDNA FLJ55130, highly similar to Rattus norvegicus tropomyosin 1, alpha (Tpm1), transcript variant 8, mRNA
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 275 aa
31.8 kDa 		No 1
TPM1-015
ENSP00000452658
ENST00000559281
H0YK48 [Direct mapping]
Tropomyosin alpha-1 chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 248 aa
28.6 kDa 		No 0
TPM1-016
ENSP00000322577
ENST00000317516
F5H7S3 [Direct mapping]
Tropomyosin alpha-1 chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 245 aa
28.5 kDa 		No 0
TPM1-018
ENSP00000351022
ENST00000358278
P09493 [Direct mapping]
Tropomyosin alpha-1 chain
D9YZV5 [Target identity:100%; Query identity:100%]
Tropomyosin 1 (Alpha) isoform 4; Tropomyosin 1 (Alpha), isoform CRA_c
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001701 [in utero embryonic development]
GO:0001725 [stress fiber]
GO:0003065 [positive regulation of heart rate by epinephrine]
GO:0003779 [actin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005862 [muscle thin filament tropomyosin]
GO:0006928 [movement of cell or subcellular component]
GO:0006936 [muscle contraction]
GO:0006937 [regulation of muscle contraction]
GO:0007010 [cytoskeleton organization]
GO:0008016 [regulation of heart contraction]
GO:0008092 [cytoskeletal protein binding]
GO:0008307 [structural constituent of muscle]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030336 [negative regulation of cell migration]
GO:0031529 [ruffle organization]
GO:0031941 [filamentous actin]
GO:0032059 [bleb]
GO:0032587 [ruffle membrane]
GO:0032781 [positive regulation of ATPase activity]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042060 [wound healing]
GO:0045214 [sarcomere organization]
GO:0045785 [positive regulation of cell adhesion]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
Show all
 284 aa
32.9 kDa 		No 0
TPM1-019
ENSP00000452999
ENST00000560445
H0YKZ6 [Direct mapping]
Tropomyosin alpha-1 chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 70 aa
8 kDa 		No 0
TPM1-022
ENSP00000453050
ENST00000560615
H0YL42 [Direct mapping]
Tropomyosin alpha-1 chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 108 aa
12.8 kDa 		No 0
TPM1-023
ENSP00000452830
ENST00000558910
H0YKJ4 [Direct mapping]
Tropomyosin alpha-1 chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 33 aa
3.7 kDa 		No 0
TPM1-024
ENSP00000453136
ENST00000560679
A0A0G2JL94 [Direct mapping]
Tropomyosin alpha-1 chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 8 aa
0.9 kDa 		No 0
TPM1-027
ENSP00000453955
ENST00000561266
H0YNC7 [Direct mapping]
Tropomyosin alpha-1 chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 223 aa
25.5 kDa 		No 0
TPM1-028
ENSP00000453941
ENST00000559556
P09493 [Direct mapping]
Tropomyosin alpha-1 chain
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003065 [positive regulation of heart rate by epinephrine]
GO:0003779 [actin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005862 [muscle thin filament tropomyosin]
GO:0006928 [movement of cell or subcellular component]
GO:0006936 [muscle contraction]
GO:0006937 [regulation of muscle contraction]
GO:0007010 [cytoskeleton organization]
GO:0008016 [regulation of heart contraction]
GO:0008092 [cytoskeletal protein binding]
GO:0008307 [structural constituent of muscle]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0030336 [negative regulation of cell migration]
GO:0031529 [ruffle organization]
GO:0032059 [bleb]
GO:0032587 [ruffle membrane]
GO:0032781 [positive regulation of ATPase activity]
GO:0034614 [cellular response to reactive oxygen species]
GO:0042060 [wound healing]
GO:0045214 [sarcomere organization]
GO:0045785 [positive regulation of cell adhesion]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
Show all
 284 aa
32.7 kDa 		No 0
TPM1-034
ENSP00000477929
ENST00000610733
A0A087WTJ7 [Direct mapping]
Tropomyosin alpha-1 chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 106 aa
12.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.