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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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IGF1R
  • TISSUE

  • CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

IGF1R

Gene description

Insulin-like growth factor 1 receptor

Protein class

Cancer-related genes
CD markers
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
RAS pathway related proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous granular cytoplasmic expression, mostly in glandular cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Uncertain based on 2 antibodies.
HPA045563 , CAB010268
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

IGF1R (HGNC Symbol)

Synonyms

CD221, IGFIR, IGFR, JTK13, MGC18216

Description

Insulin-like growth factor 1 receptor (HGNC Symbol)

Entrez gene summary

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Chromosome

15

Cytoband

q26.3

Chromosome location (bp)

98648971 - 98964530

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000140443 (version 83.38)

Entrez gene

3480

UniProt

P08069 (UniProt - Evidence at protein level)

neXtProt

NX_P08069

Antibodypedia

IGF1R antibodies

PROTEIN BROWSER

IGF1R-001
IGF1R-002
IGF1R-004
IGF1R-011
IGF1R-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IGF1R-001
ENSP00000268035
ENST00000268035
P08069 [Direct mapping]
Insulin-like growth factor 1 receptor Insulin-like growth factor 1 receptor alpha chain Insulin-like growth factor 1 receptor beta chain
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005010 [insulin-like growth factor-activated receptor activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007420 [brain development]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008544 [epidermis development]
GO:0009887 [organ morphogenesis]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030238 [male sex determination]
GO:0030335 [positive regulation of cell migration]
GO:0030879 [mammary gland development]
GO:0031017 [exocrine pancreas development]
GO:0031994 [insulin-like growth factor I binding]
GO:0032869 [cellular response to insulin stimulus]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043235 [receptor complex]
GO:0043409 [negative regulation of MAPK cascade]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043559 [insulin binding]
GO:0043560 [insulin receptor substrate binding]
GO:0045740 [positive regulation of DNA replication]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046328 [regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051262 [protein tetramerization]
GO:0051389 [inactivation of MAPKK activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060740 [prostate gland epithelium morphogenesis]
GO:0071333 [cellular response to glucose stimulus]
Show all
1367 aa
154.8 kDa
Yes 1
IGF1R-002
ENSP00000453007
ENST00000558762
C9J5X1 [Direct mapping]
Tyrosine-protein kinase receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043560 [insulin receptor substrate binding]
GO:0046777 [protein autophosphorylation]
Show all
1366 aa
154.8 kDa
Yes 1
IGF1R-004
ENSP00000453180
ENST00000560972
H0YLE7 [Direct mapping]
Insulin-like growth factor 1 receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
103 aa
11.1 kDa
No 1
IGF1R-011
ENSP00000454115
ENST00000558898
H0YNR0 [Direct mapping]
Insulin-like growth factor 1 receptor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
212 aa
24.2 kDa
No 0
IGF1R-017
ENSP00000453630
ENST00000558355
H0YMJ5 [Direct mapping]
Insulin-like growth factor 1 receptor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
190 aa
21.3 kDa
No 0

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