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USP3

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GENERAL INFORMATION

Gene name

 USP3

Gene description

 Ubiquitin specific peptidase 3

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

Mouse

 Localized to the Nucleus in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA053275 , HPA060513
SHOW MORE

ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA053275 A-431 Nucleoplasm
HPA053275 HeLa Nucleoplasm
Midbody ring Intensity Intensity
HPA053275 U-2 OS Nucleoplasm
Midbody ring Intensity Intensity
HPA060513 A549 No staining    
HPA060513 RT4 Nucleus
HPA060513 U-2 OS Nucleus

MOUSE CELLS

Main location

 Nucleus

Additional location

 Vesicles

Mouse gene

 ENSMUSG00000032376 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA053275 NIH 3T3 Nucleus
Vesicles

GENE INFORMATION

Gene name

 USP3

Synonyms

Description

 Ubiquitin specific peptidase 3 (HGNC Symbol)

Entrez gene summary

Chromosome

 15

Cytoband

 q22.31

Chromosome location (bp)

 63504511 - 63594640

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140455 (version 83.38)

Entrez gene

 9960

UniProt

 Q9Y6I4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6I4

Antibodypedia

 USP3 antibodies

PROTEIN BROWSER
USP3-001
USP3-004
USP3-006
USP3-009
USP3-010
USP3-012
USP3-014
USP3-201
USP3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USP3-001
ENSP00000369681
ENST00000380324
Q9Y6I4 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000790 [nuclear chromatin]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005634 [nucleus]
GO:0006281 [DNA repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008270 [zinc ion binding]
GO:0016578 [histone deubiquitination]
GO:0016579 [protein deubiquitination]
GO:0031647 [regulation of protein stability]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0042393 [histone binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 520 aa
58.9 kDa 		No 0
USP3-004
ENSP00000453619
ENST00000558285
H0YMI4 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008270 [zinc ion binding]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 503 aa
57.4 kDa 		Yes 0
USP3-006
ENSP00000453138
ENST00000559711
H0YLB7 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 431 aa
49.1 kDa 		No 0
USP3-009
ENSP00000453093
ENST00000559771
H0YL81 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 126 aa
14.5 kDa 		No 0
USP3-010
ENSP00000454197
ENST00000559276
H0YNX9 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 39 aa
4.4 kDa 		No 0
USP3-012
ENSP00000453688
ENST00000561442
H0YMP6 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 132 aa
14.6 kDa 		No 0
USP3-014
ENSP00000453194
ENST00000560070
H0YLG0 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008270 [zinc ion binding]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 133 aa
14.5 kDa 		No 0
USP3-201
ENSP00000268049
ENST00000268049
Q6JHV3 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008270 [zinc ion binding]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 498 aa
56.6 kDa 		No 0
USP3-202
ENSP00000445828
ENST00000540797
Q9Y6I4 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000790 [nuclear chromatin]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005634 [nucleus]
GO:0006281 [DNA repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008270 [zinc ion binding]
GO:0016578 [histone deubiquitination]
GO:0016579 [protein deubiquitination]
GO:0031647 [regulation of protein stability]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0042393 [histone binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 476 aa
53.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.