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Cytochrome P450, family 11, subfamily A, polypeptide 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Oxidoreductases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005506 [iron ion binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0006700 [C21-steroid hormone biosynthetic process] GO:0006704 [glucocorticoid biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0008202 [steroid metabolic process] GO:0008203 [cholesterol metabolic process] GO:0008386 [cholesterol monooxygenase (side-chain-cleaving) activity] GO:0016125 [sterol metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0020037 [heme binding] GO:0034650 [cortisol metabolic process] GO:0042359 [vitamin D metabolic process] GO:0044281 [small molecule metabolic process] GO:0044550 [secondary metabolite biosynthetic process] GO:0055114 [oxidation-reduction process] GO:0071375 [cellular response to peptide hormone stimulus]
Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0006700 [C21-steroid hormone biosynthetic process] GO:0006704 [glucocorticoid biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0008202 [steroid metabolic process] GO:0008203 [cholesterol metabolic process] GO:0008386 [cholesterol monooxygenase (side-chain-cleaving) activity] GO:0016125 [sterol metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0020037 [heme binding] GO:0034650 [cortisol metabolic process] GO:0042359 [vitamin D metabolic process] GO:0044281 [small molecule metabolic process] GO:0044550 [secondary metabolite biosynthetic process] GO:0055114 [oxidation-reduction process] GO:0071375 [cellular response to peptide hormone stimulus]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process]
MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process]
