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PCSK6

GENERAL INFORMATION

Gene name

 PCSK6

Gene description

 Proprotein convertase subtilisin/kexin type 6

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (spleen, liver)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic staining in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA004774
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PCSK6 (HGNC Symbol)

Synonyms

 PACE4, SPC4

Description

 Proprotein convertase subtilisin/kexin type 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]

Chromosome

 15

Cytoband

 q26.3

Chromosome location (bp)

 101297142 - 101525202

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140479 (version 83.38)

Entrez gene

 5046

UniProt

 P29122 (UniProt - Evidence at protein level)

neXtProt

 NX_P29122

Antibodypedia

 PCSK6 antibodies

PROTEIN BROWSER
«
PCSK6-001
PCSK6-002
PCSK6-003
PCSK6-004
PCSK6-005
PCSK6-008
PCSK6-010
PCSK6-011
PCSK6-012
PCSK6-016
PCSK6-017
PCSK6-019
PCSK6-020
PCSK6-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PCSK6-001
ENSP00000482760
ENST00000611716
P29122 [Direct mapping]
Proprotein convertase subtilisin/kexin type 6
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005796 [Golgi lumen]
GO:0006508 [proteolysis]
GO:0007354 [zygotic determination of anterior/posterior axis, embryo]
GO:0007368 [determination of left/right symmetry]
GO:0008201 [heparin binding]
GO:0008233 [peptidase activity]
GO:0009100 [glycoprotein metabolic process]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016485 [protein processing]
GO:0016486 [peptide hormone processing]
GO:0030510 [regulation of BMP signaling pathway]
GO:0031012 [extracellular matrix]
GO:0032455 [nerve growth factor processing]
GO:0032902 [nerve growth factor production]
GO:0032940 [secretion by cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048406 [nerve growth factor binding]
Show all
 969 aa
106.4 kDa 		No 0
PCSK6-002
ENSP00000477768
ENST00000611967
P29122 [Direct mapping]
Proprotein convertase subtilisin/kexin type 6
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005796 [Golgi lumen]
GO:0006508 [proteolysis]
GO:0008201 [heparin binding]
GO:0009100 [glycoprotein metabolic process]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016485 [protein processing]
GO:0016486 [peptide hormone processing]
GO:0030510 [regulation of BMP signaling pathway]
GO:0031012 [extracellular matrix]
GO:0032455 [nerve growth factor processing]
GO:0032902 [nerve growth factor production]
GO:0032940 [secretion by cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048406 [nerve growth factor binding]
Show all
 652 aa
71.8 kDa 		No 0
PCSK6-003
ENSP00000481556
ENST00000622483
A0A087WY68 [Direct mapping]
Proprotein convertase subtilisin/kexin type 6
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0006508 [proteolysis]
Show all
 975 aa
106.6 kDa 		No 0
PCSK6-004
ENSP00000482831
ENST00000619160
A0A087WZR0 [Direct mapping]
Proprotein convertase subtilisin/kexin type 6
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0006508 [proteolysis]
Show all
 962 aa
105.3 kDa 		No 0
PCSK6-005
ENSP00000479496
ENST00000618548
P29122 [Direct mapping]
Proprotein convertase subtilisin/kexin type 6
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005796 [Golgi lumen]
GO:0006508 [proteolysis]
GO:0008201 [heparin binding]
GO:0008233 [peptidase activity]
GO:0009100 [glycoprotein metabolic process]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016485 [protein processing]
GO:0016486 [peptide hormone processing]
GO:0030510 [regulation of BMP signaling pathway]
GO:0031012 [extracellular matrix]
GO:0032455 [nerve growth factor processing]
GO:0032902 [nerve growth factor production]
GO:0032940 [secretion by cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048406 [nerve growth factor binding]
Show all
 956 aa
105.1 kDa 		No 0
PCSK6-008
ENSP00000381246
ENST00000398185
H0Y3Q0 [Direct mapping]
Proprotein convertase subtilisin/kexin type 6
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
Show all
 797 aa
88.6 kDa 		No 0
PCSK6-010
ENSP00000452997
ENST00000559417
H0YKZ4 [Direct mapping]
Proprotein convertase subtilisin/kexin type 6
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
Show all
 345 aa
38 kDa 		No 0
PCSK6-011
ENSP00000452839
ENST00000558864
H0YKK2 [Direct mapping]
Proprotein convertase subtilisin/kexin type 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 77 aa
8.3 kDa 		No 0
PCSK6-012
ENSP00000453771
ENST00000558951
H0YMW5 [Direct mapping]
Proprotein convertase subtilisin/kexin type 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
Show all
 125 aa
14.1 kDa 		No 0
PCSK6-016
ENSP00000483048
ENST00000621185
A0A087X025 [Direct mapping]
Proprotein convertase subtilisin/kexin type 6
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
Show all
 142 aa
16.2 kDa 		No 0
PCSK6-017
ENSP00000453155
ENST00000559605
H0YLC8 [Direct mapping]
Proprotein convertase subtilisin/kexin type 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 126 aa
13.1 kDa 		No 0
PCSK6-019
ENSP00000478081
ENST00000615296
P29122 [Direct mapping]
Proprotein convertase subtilisin/kexin type 6
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005796 [Golgi lumen]
GO:0006508 [proteolysis]
GO:0008201 [heparin binding]
GO:0009100 [glycoprotein metabolic process]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016485 [protein processing]
GO:0016486 [peptide hormone processing]
GO:0030510 [regulation of BMP signaling pathway]
GO:0031012 [extracellular matrix]
GO:0032455 [nerve growth factor processing]
GO:0032902 [nerve growth factor production]
GO:0032940 [secretion by cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048406 [nerve growth factor binding]
Show all
 623 aa
68.2 kDa 		No 0
PCSK6-020
ENSP00000487813
ENST00000632686
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008233 [peptidase activity]
Show all
 308 aa
33.9 kDa 		No 0
PCSK6-201
ENSP00000332052
ENST00000331826
H7BXT3 [Direct mapping]
Proprotein convertase subtilisin/kexin type 6
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
Show all
 664 aa
73 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.