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FURIN

CANCER ATLAS

Gene description

 Furin (paired basic amino acid cleaving enzyme)

Protein class

 Enzymes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB009499

GENE INFORMATION

Gene name

 FURIN (HGNC Symbol)

Synonyms

 FUR, PACE, PCSK3, SPC1

Description

 Furin (paired basic amino acid cleaving enzyme) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Chromosome

 15

Cytoband

 q26.1

Chromosome location (bp)

 90868592 - 90883458

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140564 (version 83.38)

Entrez gene

 5045

UniProt

 P09958 (UniProt - Evidence at protein level)

neXtProt

 NX_P09958

Antibodypedia

 FURIN antibodies

PROTEIN BROWSER
FURIN-001
FURIN-003
FURIN-005
FURIN-201
FURIN-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FURIN-001
ENSP00000268171
ENST00000268171
P09958 [Direct mapping]
Furin
A0A024RC70 [Target identity:100%; Query identity:100%]
Furin (Paired basic amino acid cleaving enzyme), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002020 [protease binding]
GO:0004175 [endopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005796 [Golgi lumen]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0006465 [signal peptide processing]
GO:0006508 [proteolysis]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0008233 [peptidase activity]
GO:0008283 [cell proliferation]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016485 [protein processing]
GO:0016486 [peptide hormone processing]
GO:0017187 [peptidyl-glutamic acid carboxylation]
GO:0019058 [viral life cycle]
GO:0019068 [virion assembly]
GO:0019082 [viral protein processing]
GO:0022617 [extracellular matrix disassembly]
GO:0030140 [trans-Golgi network transport vesicle]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0032455 [nerve growth factor processing]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0032902 [nerve growth factor production]
GO:0032911 [negative regulation of transforming growth factor beta1 production]
GO:0032940 [secretion by cell]
GO:0042176 [regulation of protein catabolic process]
GO:0042277 [peptide binding]
GO:0043043 [peptide biosynthetic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045121 [membrane raft]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048406 [nerve growth factor binding]
GO:0051044 [positive regulation of membrane protein ectodomain proteolysis]
GO:0052548 [regulation of endopeptidase activity]
GO:0070062 [extracellular exosome]
Show all
 794 aa
86.7 kDa 		Yes 1
FURIN-003
ENSP00000452730
ENST00000559353
H0YKB2 [Direct mapping]
Furin
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 69 aa
7.7 kDa 		Yes 0
FURIN-005
ENSP00000453212
ENST00000560824
H0YLH7 [Direct mapping]
Furin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
Show all
 175 aa
19.8 kDa 		Yes 0
FURIN-201
ENSP00000484952
ENST00000610579
P09958 [Direct mapping]
Furin
A0A024RC70 [Target identity:100%; Query identity:100%]
Furin (Paired basic amino acid cleaving enzyme), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002020 [protease binding]
GO:0004175 [endopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005796 [Golgi lumen]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0006465 [signal peptide processing]
GO:0006508 [proteolysis]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0008233 [peptidase activity]
GO:0008283 [cell proliferation]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016485 [protein processing]
GO:0016486 [peptide hormone processing]
GO:0017187 [peptidyl-glutamic acid carboxylation]
GO:0019058 [viral life cycle]
GO:0019068 [virion assembly]
GO:0019082 [viral protein processing]
GO:0022617 [extracellular matrix disassembly]
GO:0030140 [trans-Golgi network transport vesicle]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0032455 [nerve growth factor processing]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0032902 [nerve growth factor production]
GO:0032911 [negative regulation of transforming growth factor beta1 production]
GO:0032940 [secretion by cell]
GO:0042176 [regulation of protein catabolic process]
GO:0042277 [peptide binding]
GO:0043043 [peptide biosynthetic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045121 [membrane raft]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048406 [nerve growth factor binding]
GO:0051044 [positive regulation of membrane protein ectodomain proteolysis]
GO:0052548 [regulation of endopeptidase activity]
GO:0070062 [extracellular exosome]
Show all
 794 aa
86.7 kDa 		Yes 1
FURIN-202
ENSP00000483552
ENST00000618099
P09958 [Direct mapping]
Furin
A0A024RC70 [Target identity:100%; Query identity:100%]
Furin (Paired basic amino acid cleaving enzyme), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002020 [protease binding]
GO:0004175 [endopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005796 [Golgi lumen]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0006465 [signal peptide processing]
GO:0006508 [proteolysis]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007568 [aging]
GO:0008233 [peptidase activity]
GO:0008283 [cell proliferation]
GO:0009966 [regulation of signal transduction]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016485 [protein processing]
GO:0016486 [peptide hormone processing]
GO:0017187 [peptidyl-glutamic acid carboxylation]
GO:0019058 [viral life cycle]
GO:0019068 [virion assembly]
GO:0019082 [viral protein processing]
GO:0022617 [extracellular matrix disassembly]
GO:0030140 [trans-Golgi network transport vesicle]
GO:0030198 [extracellular matrix organization]
GO:0030335 [positive regulation of cell migration]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030574 [collagen catabolic process]
GO:0031985 [Golgi cisterna]
GO:0032455 [nerve growth factor processing]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0032902 [nerve growth factor production]
GO:0032911 [negative regulation of transforming growth factor beta1 production]
GO:0032940 [secretion by cell]
GO:0042176 [regulation of protein catabolic process]
GO:0042277 [peptide binding]
GO:0043043 [peptide biosynthetic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045121 [membrane raft]
GO:0045714 [regulation of low-density lipoprotein particle receptor biosynthetic process]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048406 [nerve growth factor binding]
GO:0051044 [positive regulation of membrane protein ectodomain proteolysis]
GO:0052548 [regulation of endopeptidase activity]
GO:0070062 [extracellular exosome]
Show all
 794 aa
86.7 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.