Cell atlas - CRTC3 - The Human Protein Atlas

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CRTC3

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CRTC3
Gene description	CREB regulated transcription coactivator 3
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Additional location	In addition localized to the Cytosol (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA043735 , HPA063691
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (validated)

Additional location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA043735	A-431	Nucleoplasm
	HPA043735	A-431	Cytosol
	HPA043735	U-2 OS	Nucleoplasm
	HPA043735	U-2 OS	Cytosol
	HPA043735	U-251 MG	Nucleoplasm
	HPA043735	U-251 MG	Cytosol
	HPA063691	HeLa	Nucleoplasm	Intensity
	HPA063691	HeLa	Cytosol
	HPA063691	SiHa	Nucleoplasm	Intensity
	HPA063691	SiHa	Cytosol
	HPA063691	U-2 OS	Nucleoplasm	Intensity

GENE INFORMATION
Gene name	CRTC3 (HGNC Symbol)
Synonyms	FLJ21868
Description	CREB regulated transcription coactivator 3 (HGNC Symbol)
Entrez gene summary	This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Chromosome	15
Cytoband	q26.1
Chromosome location (bp)	90529925 - 90645345
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140577 (version 83.38)
Entrez gene	64784
UniProt	Q6UUV7 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UUV7
Antibodypedia	CRTC3 antibodies

PROTEIN BROWSER

CRTC3-001	CRTC3-002	CRTC3-012	CRTC3-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRTC3-001 ENSP00000268184 ENST00000268184	Q6UUV7 [Direct mapping] CREB-regulated transcription coactivator 3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008140 [cAMP response element binding protein binding] GO:0016032 [viral process] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0042116 [macrophage activation] GO:0043951 [negative regulation of cAMP-mediated signaling] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050995 [negative regulation of lipid catabolic process] GO:0051289 [protein homotetramerization] GO:0097009 [energy homeostasis] Show all	619 aa 67 kDa	No	0
CRTC3-002 ENSP00000416573 ENST00000420329	Q6UUV7 [Direct mapping] CREB-regulated transcription coactivator 3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008140 [cAMP response element binding protein binding] GO:0016032 [viral process] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0042116 [macrophage activation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051289 [protein homotetramerization] Show all	618 aa 66.8 kDa	No	0
CRTC3-012 ENSP00000452640 ENST00000560098	H0YK33 [Direct mapping] CREB-regulated transcription coactivator 3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008140 [cAMP response element binding protein binding] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051289 [protein homotetramerization] Show all	91 aa 10.2 kDa	No	0
CRTC3-014 ENSP00000452676 ENST00000558005	H0YK64 [Direct mapping] CREB-regulated transcription coactivator 3 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008140 [cAMP response element binding protein binding] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	190 aa 20.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.