Cell atlas - SEC11A - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SEC11A
Gene description	SEC11 homolog A, signal peptidase complex subunit
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane. In addition localized to the Golgi apparatus. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (approved)
Additional location	In addition localized to the Golgi apparatus (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA047533
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane. In addition localized to the Golgi apparatus. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nuclear membrane (approved)

Additional location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA047533	Hep G2	Nuclear membrane	Intensity
HPA047533	Hep G2	Golgi apparatus	Intensity
HPA047533	MCF7	Nuclear membrane
HPA047533	U-2 OS	No staining

GENE INFORMATION
Gene name	SEC11A (HGNC Symbol)
Synonyms	SEC11L1, sid2895, SPC18, SPCS4A
Description	SEC11 homolog A, signal peptidase complex subunit (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]
Chromosome	15
Cytoband
Chromosome location (bp)	84669538 - 84716716
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140612 (version 83.38)
Entrez gene	23478
UniProt	P67812 (UniProt - Evidence at protein level)
neXtProt	NX_P67812
Antibodypedia	SEC11A antibodies

PROTEIN BROWSER

SEC11A-001	SEC11A-002	SEC11A-003	SEC11A-004	SEC11A-008	SEC11A-009	SEC11A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEC11A-001 ENSP00000268220 ENST00000268220	P67812 [Direct mapping] Signal peptidase complex catalytic subunit SEC11A A0A024RC78 [Target identity:100%; Query identity:100%] Signal peptidase complex catalytic subunit SEC11 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006412 [translation] GO:0006465 [signal peptide processing] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0044267 [cellular protein metabolic process] GO:0050796 [regulation of insulin secretion] GO:0070062 [extracellular exosome] Show all	179 aa 20.6 kDa	No	1
SEC11A-002 ENSP00000413121 ENST00000455959	P67812 [Direct mapping] Signal peptidase complex catalytic subunit SEC11A Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006412 [translation] GO:0006465 [signal peptide processing] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0044267 [cellular protein metabolic process] GO:0050796 [regulation of insulin secretion] GO:0070062 [extracellular exosome] Show all	153 aa 17.4 kDa	No	1
SEC11A-003 ENSP00000454193 ENST00000558196	H0YNX5 [Direct mapping] Signal peptidase complex catalytic subunit SEC11 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006465 [signal peptide processing] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	106 aa 12 kDa	No	0
SEC11A-004 ENSP00000452684 ENST00000560266	P67812 [Direct mapping] Signal peptidase complex catalytic subunit SEC11A Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006412 [translation] GO:0006465 [signal peptide processing] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0044267 [cellular protein metabolic process] GO:0050796 [regulation of insulin secretion] GO:0070062 [extracellular exosome] Show all	164 aa 19 kDa	No	1
SEC11A-008 ENSP00000452697 ENST00000558134	P67812 [Direct mapping] Signal peptidase complex catalytic subunit SEC11A Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006412 [translation] GO:0006465 [signal peptide processing] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0044267 [cellular protein metabolic process] GO:0050796 [regulation of insulin secretion] GO:0070062 [extracellular exosome] Show all	185 aa 21.5 kDa	No	1
SEC11A-009 ENSP00000453930 ENST00000558217	H0YNA5 [Direct mapping] Signal peptidase I Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006465 [signal peptide processing] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	135 aa 15.6 kDa	No	2
SEC11A-201 ENSP00000452932 ENST00000559729	H0YKT4 [Direct mapping] Signal peptidase complex catalytic subunit SEC11A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006465 [signal peptide processing] GO:0008236 [serine-type peptidase activity] GO:0016021 [integral component of membrane] Show all	129 aa 14.9 kDa	No	2