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SEPT12

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GENERAL INFORMATION

Gene name

 SEPT12

Gene description

 Septin 12

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the microtubules.

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Localized to the Microtubules (uncertain)

DATA RELIABILITY

Reliability score

 Uncertain based on 1 antibody.
HPA041128
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the microtubules.

Main location

 Microtubules (uncertain)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA041128 A-431 Microtubules
HPA041128 U-2 OS Microtubules
HPA041128 U-251 MG Microtubules

GENE INFORMATION

Gene name

 SEPT12 (HGNC Symbol)

Synonyms

 FLJ25410

Description

 Septin 12 (HGNC Symbol)

Entrez gene summary

 This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 4777669 - 4788521

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140623 (version 83.38)

Entrez gene

 124404

UniProt

 Q8IYM1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IYM1

Antibodypedia

 SEPT12 antibodies

PROTEIN BROWSER
SEPT12-001
SEPT12-003
SEPT12-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SEPT12-001
ENSP00000268231
ENST00000268231
Q8IYM1 [Direct mapping]
Septin-12
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
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GO:0001725 [stress fiber]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005819 [spindle]
GO:0007049 [cell cycle]
GO:0015630 [microtubule cytoskeleton]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031105 [septin complex]
GO:0032154 [cleavage furrow]
GO:0035091 [phosphatidylinositol binding]
GO:0042803 [protein homodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051301 [cell division]
GO:0097227 [sperm annulus]
Show all
 358 aa
40.7 kDa 		No 0
SEPT12-003
ENSP00000379922
ENST00000396693
Q8IYM1 [Direct mapping]
Septin-12
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001725 [stress fiber]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005819 [spindle]
GO:0007049 [cell cycle]
GO:0015630 [microtubule cytoskeleton]
GO:0019003 [GDP binding]
GO:0030496 [midbody]
GO:0031105 [septin complex]
GO:0032154 [cleavage furrow]
GO:0035091 [phosphatidylinositol binding]
GO:0042803 [protein homodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051301 [cell division]
GO:0097227 [sperm annulus]
Show all
 312 aa
35.2 kDa 		No 0
SEPT12-007
ENSP00000467281
ENST00000591624
K7EP92 [Direct mapping]
Septin-12
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Show all
GO:0005525 [GTP binding]
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 64 aa
6.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.