Fields »
ABOUT
HELP
BLOG
SLC5A2

GENERAL INFORMATION

Gene name

 SLC5A2

Gene description

 Solute carrier family 5 (sodium/glucose cotransporter), member 2

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (kidney)
GTEx:Group enriched (kidney, testis)
FANTOM5:Tissue enriched (kidney)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous expression in proximal tubules in kidney

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA041603
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (kidney, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)

GENE INFORMATION

Gene name

 SLC5A2 (HGNC Symbol)

Synonyms

 SGLT2

Description

 Solute carrier family 5 (sodium/glucose cotransporter), member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015]

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 31483002 - 31490860

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140675 (version 83.38)

Entrez gene

 6524

UniProt

 P31639 (UniProt - Evidence at protein level)

neXtProt

 NX_P31639

Antibodypedia

 SLC5A2 antibodies

PROTEIN BROWSER
SLC5A2-001
SLC5A2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC5A2-001
ENSP00000327943
ENST00000330498
P31639 [Direct mapping]
Sodium/glucose cotransporter 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005362 [low-affinity glucose:sodium symporter activity]
GO:0005412 [glucose:sodium symporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006810 [transport]
GO:0006814 [sodium ion transport]
GO:0015758 [glucose transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031526 [brush border membrane]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1904659 [glucose transmembrane transport]
Show all
 672 aa
72.9 kDa 		No >9
SLC5A2-005
ENSP00000455143
ENST00000569576
H3BP44 [Direct mapping]
Sodium/glucose cotransporter 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
Show all
 149 aa
16.1 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.