Cell atlas - ARMC5 - The Human Protein Atlas

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ARMC5

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Focal adhesion sites
	Nucleoplasm

Human cell
	Actin Filaments
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ARMC5
Gene description	Armadillo repeat containing 5
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & nucleoplasm. In addition localized to the focal adhesion sites.
RNA cell category	Cell line enhanced (NB-4)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)
Additional location	In addition localized to the Focal adhesion sites (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA063706
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NB-4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & nucleoplasm. In addition localized to the focal adhesion sites.

Main location

Nucleoplasm (approved), Cytosol (approved)

Additional location

Focal adhesion sites (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA063706	HEK 293	Nucleoplasm
	HPA063706	HEK 293	Cytosol
	HPA063706	MCF7	Nucleoplasm
	HPA063706	MCF7	Cytosol
	HPA063706	U-2 OS	Nucleoplasm
			Focal adhesion sites
			Cytosol

GENE INFORMATION
Gene name	ARMC5 (HGNC Symbol)
Synonyms	FLJ13063
Description	Armadillo repeat containing 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ARM (armadillo/beta-catenin-like repeat) superfamily. The ARM repeat is a tandemly repeated sequence motif with approximately 40 amino acid long. This repeat is implicated in mediating protein-protein interactions. The encoded protein contains seven ARM repeats. Mutations in this gene are associated with primary bilateral macronodular adrenal hyperplasia, which is also known as ACTH-independent macronodular adrenal hyperplasia 2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	31458080 - 31467166
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140691 (version 83.38)
Entrez gene	79798
UniProt	Q96C12 (UniProt - Evidence at protein level)
neXtProt	NX_Q96C12
Antibodypedia	ARMC5 antibodies

PROTEIN BROWSER

ARMC5-001	ARMC5-002	ARMC5-003	ARMC5-004	ARMC5-201	ARMC5-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARMC5-001 ENSP00000386125 ENST00000408912	J3KQ26 [Direct mapping] Armadillo repeat-containing protein 5 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] Show all	1030 aa 108.1 kDa	No	0
ARMC5-002 ENSP00000399561 ENST00000457010	Q96C12 [Direct mapping] Armadillo repeat-containing protein 5 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] Show all	725 aa 75.6 kDa	Yes	0
ARMC5-003 ENSP00000456877 ENST00000563544	Q96C12 [Direct mapping] Armadillo repeat-containing protein 5 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] Show all	935 aa 97.7 kDa	Yes	0
ARMC5-004 ENSP00000456571 ENST00000564900	H3BS74 [Direct mapping] Armadillo repeat-containing protein 5 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] Show all	598 aa 63.1 kDa	No	0
ARMC5-201 ENSP00000268314 ENST00000268314	Q96C12 [Direct mapping] Armadillo repeat-containing protein 5 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] Show all	935 aa 97.7 kDa	Yes	0
ARMC5-202 ENSP00000443995 ENST00000538189	Q96C12 [Direct mapping] Armadillo repeat-containing protein 5 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] Show all	771 aa 81.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.