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PARN

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GENERAL INFORMATION

Gene name

 PARN

Gene description

 Poly(A)-specific ribonuclease

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoli & nuclear speckles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli (approved), Nuclear speckles (approved)

DATA RELIABILITY

Reliability score

 Approved based on 2 antibodies.
HPA006314 , CAB011673
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoli & nuclear speckles.

Main location

 Nucleoli (approved), Nuclear speckles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB011673 A-431 Nucleoli
Cytosol
CAB011673 U-2 OS Nucleoli
CAB011673 U-251 MG Nucleoli
HPA006314 A-431 Nuclear speckles
HPA006314 U-2 OS Nuclear speckles
HPA006314 U-251 MG Nuclear speckles

GENE INFORMATION

Gene name

 PARN (HGNC Symbol)

Synonyms

 DAN

Description

 Poly(A)-specific ribonuclease (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Chromosome

 16

Cytoband

 p13.12

Chromosome location (bp)

 14435701 - 14632728

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140694 (version 83.38)

Entrez gene

 5073

UniProt

 O95453 (UniProt - Evidence at protein level)

neXtProt

 NX_O95453

Antibodypedia

 PARN antibodies

PROTEIN BROWSER
PARN-001
PARN-002
PARN-003
PARN-004
PARN-006
PARN-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PARN-001
ENSP00000387911
ENST00000437198
O95453 [Direct mapping]
Poly(A)-specific ribonuclease PARN
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0004518 [nuclease activity]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006402 [mRNA catabolic process]
GO:0007292 [female gamete generation]
GO:0009451 [RNA modification]
GO:0010467 [gene expression]
GO:0019901 [protein kinase binding]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 639 aa
73.5 kDa 		No 0
PARN-002
ENSP00000345456
ENST00000341484
O95453 [Direct mapping]
Poly(A)-specific ribonuclease PARN
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0004518 [nuclease activity]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006402 [mRNA catabolic process]
GO:0007292 [female gamete generation]
GO:0009451 [RNA modification]
GO:0010467 [gene expression]
GO:0019901 [protein kinase binding]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 578 aa
66.6 kDa 		No 0
PARN-003
ENSP00000410525
ENST00000420015
O95453 [Direct mapping]
Poly(A)-specific ribonuclease PARN
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0004518 [nuclease activity]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006402 [mRNA catabolic process]
GO:0007292 [female gamete generation]
GO:0009451 [RNA modification]
GO:0010467 [gene expression]
GO:0019901 [protein kinase binding]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 593 aa
67.7 kDa 		No 0
PARN-004
ENSP00000444381
ENST00000539279
O95453 [Direct mapping]
Poly(A)-specific ribonuclease PARN
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0004518 [nuclease activity]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006402 [mRNA catabolic process]
GO:0007292 [female gamete generation]
GO:0009451 [RNA modification]
GO:0010467 [gene expression]
GO:0019901 [protein kinase binding]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 464 aa
53 kDa 		No 0
PARN-006
ENSP00000456982
ENST00000562896
H3BT23 [Direct mapping]
Poly(A)-specific ribonuclease PARN
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
Show all
 109 aa
12.3 kDa 		No 0
PARN-010
ENSP00000456279
ENST00000569444
H3BRK1 [Direct mapping]
Poly(A)-specific ribonuclease PARN
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
Show all
 261 aa
29.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.